To document cardiac function before and after treatment of CS.
ID
Source
Brief title
Condition
- Cardiac disorders, signs and symptoms NEC
- Hypothalamus and pituitary gland disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Echocardiographic parameters of systolic and diastolic function.
Secondary outcome
not applicable.
Background summary
Cardiovascular diseases occur more frequently in patients with CS. Other rare
hormone excess syndromes, like acromegaly and prolactinoma, have been
associated with cardiac abnormalities. In untreated CS, anecdotal reports
indicate that a cardiomyopathy is not uncommon. The effect of treatment of CS
on cardiac function remains to be established.
Study objective
To document cardiac function before and after treatment of CS.
Study design
Open, observational, prospective study in 16 patients with CS.
Study burden and risks
3 x ultrasounds of the heart (45 minutes each). There are no known long-term
adverse events of echocardiography.
Albinusdreef 2
2333 ZA Leiden
NL
Albinusdreef 2
2333 ZA Leiden
NL
Listed location countries
Age
Inclusion criteria
Cushing's Syndrome as biochemically and clinically proven.
Age 18-70 years
Exclusion criteria
History of cancer
Untreated hypertension or poorly controlled diabetes
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL25832.058.08 |