Primary Objective: to investigate the cortical event related related potentials to repetitive nociceptive stimuli in patients with chronic pain compared to patients without pain.Secondary Objectives:to investigate the relation between DNIC response…
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
Chronische pijn
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
N1-P2 peak-to-peak and P300 amplitudes in the event related potentials (EEG).
Secondary outcome
1. The quantification of DNIC response 2. The quantification of the subjective
intensity of pain 3. The quantification of the nature of pain 4. Baseline
parameters: date of birth, date of surgery, treatment technique, medication
intake, duration of pain suffering, medical co-morbidity (neurological
diseases, psychiatric diseases or diabetes).
Background summary
Chronic neuropathic pain is a major problem since it is difficult to treat and
the understanding of the underlying neurobiology is sparse. Chronic pain is
accompanied with hyperalgesia, an increased pain sensitivity. Long-term
potentiation (LTP) at synapses of nociceptive nerve fibers is a proposed
cellular mechanism underlying some forms of hyperalgesia, and is believed to be
one of the key mechanisms underlying chronic pain. A decrease in pain
thresholds out of the stimulated and segmental area are an indication for
generalized hyperalgesia. A state of generalized hyperalgesia would at least
suggest involvement of supraspinal areas in the context of LTP induction.
Study objective
Primary Objective:
to investigate the cortical event related related potentials to repetitive
nociceptive stimuli in patients with chronic pain compared to patients without
pain.
Secondary Objectives:
to investigate the relation between DNIC response and the response on
repetitive nociceptive stimuli in both groups, measured by event related
potentials in the electroencephalogram.
to investigate the relations between the subjective intensity of pain and the
response on repetitive nociceptive stimuli in patients with chronic pain,
measured by event related potentials in the electroencephalogram.
to investigate the relations between the nature of pain and the response on
repetitive nociceptive stimuli in patients with chronic pain, measured by event
related potentials in the electroencephalogram.
Study design
This is an observational study, based on a cross-sectional repeated measures
design in a patientgroup and controlgroup.
Study burden and risks
not applicable
Geert grooteplein 10
6525 GA
Nederland
Geert grooteplein 10
6525 GA
Nederland
Listed location countries
Age
Inclusion criteria
Patients after lumpectomy or mastecomy and an axillary lymph node dissection; 1 to 3 years post OK
Patients with pain presented longer than 3 months, will be included in de chronic pain group
Aged 18 - 65 years
Women
Exclusion criteria
Actual presence of (breast)cancer or metastases.
Presence or history of neurological (other than chronic pain) or major psychiatric diseases.
Regular intake of medication affecting potentially brain function or EEG signal.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL30189.091.09 |