The goal of this study is to collect large cohorts of patients with various multifactorial eye diseases. The study cohorts will be used to identify genetic risk factors for these diseases.
ID
Source
Brief title
Condition
- Vision disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
We will study genetic variants and compare their frequencies between patients
and control individuals.
Secondary outcome
Not applicable.
Background summary
The most common causes of vision impairment and blindness are age-related
macular degeneration (AMD), glaucoma, cataract and diabetic retinopathy. These
are multifactorial diseases, which means that they are caused by a combination
of genetic and environmental factors. Genetic research on AMD has revealed that
the complement system plays an important role in the disease pathogenesis. The
genetic causes of other multifactorial eye diseases are still poorly
understood.
Study objective
The goal of this study is to collect large cohorts of patients with various
multifactorial eye diseases. The study cohorts will be used to identify genetic
risk factors for these diseases.
Study design
Case-control study. Blood will be drawn from patients with multifactorial eye
diseases, such as glaucoma, retinal detachment, and several less common
multifactorial diseases: multifocal choroiditis, idiopathic perifoveal
teleangiectasis, retinitis centralis serosa, optic disc drusen and
microphthalmia. Control individuals have already been collected. The frequency
of genetic variants will be compared between cases and healthy control
individuals.
Study burden and risks
De burden of the study for the patient (one blood withdrawal) is minimal.
Philips van Leydenlaan 15
6525 EX Nijmegen
NL
Philips van Leydenlaan 15
6525 EX Nijmegen
NL
Listed location countries
Age
Inclusion criteria
Patients with one of the following mulitifactorial eye diseases: glaucoma, retinal detachment, multifocal choroiditis, idiopathic perifoveal teleangiectasis, retinitis centralis serosa, optic disc drusen, microphthalmia
Exclusion criteria
Patients that do not have a mulitfactorial eye disease mentioned in the inclusion criteria.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL29642.091.09 |