The main aims of the proposed study were (1) to determine the effect of delirium on cognitive-, psychological-, functional-, and health outcomes at discharge, 3, 6 and 12 month follow-up. Patients with a delirium at admission will be compared with…
ID
Source
Brief title
Condition
- Deliria (incl confusion)
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Primary: Cognitive and psychological functioning over time.
Secondary outcome
Secondary: All-cause mortality, morbidity.
Background summary
Delirium is one of the most common neuropsychiatric complications in older
patients admitted to the hospital. Few studies have examined how cognition and
psychological factors develop over time after a delirious episode. Furthermore,
there is only a paucity of studies that have taken into account different
onsets and subtypes of delirium. In order to develop interventions, however, it
is important to have a clear view of (a) effects of delirium on cogntive and
psychological fucntioning and different health outcomes and (b) factors that
influence cognitive and psychological functioning after delirium.
Study objective
The main aims of the proposed study were (1) to determine the effect of
delirium on cognitive-, psychological-, functional-, and health outcomes at
discharge, 3, 6 and 12 month follow-up. Patients with a delirium at admission
will be compared with those who develop one in hospital. Within these two
groups, the three delirium subtypes will be differentiated. The delirious
patient groups will also be compared with an age-matched control group; (2) to
identify factors that may influence psychological and cognitive functioning and
health outcomes in (a) elderly patients with delirium at hospital admission and
(b) those who develop delirium during their hospital stay, and to determine
whether there are any differences between these risk factors for the three
delirium subtypes.
Study design
A longitudinal and cross-sectional design will examine the effect of delirium
on a variety of outcomes.
Study burden and risks
Burden: At discharge and at follow up patients will participate in cognitive
tests and fill out questionnaires. This will take approximately 2 hours each
time, including breaks. Assessing cognitive functioning with the MMSE and
sometimes with the CAMCOG is standard clinical care in the TweeSteden hospital,
but adding questionnaires to this procedure is not. During follow-up, patients*
assessment will take place after a control-appointment by the geriatric
physician.
Risks: In our opinion, there are no risks associated with participation. The
principal investigator, project leader or geriatric physician can decide to
exclude a patient from the study for urgent medical reasons.
Postbus 90107
5000 LA
NL
Postbus 90107
5000 LA
NL
Listed location countries
Age
Inclusion criteria
Inclusion criteria patient group: All patients who are admitted to the Department of Geriatrics with a delirium or who develop a delirium during their hospital stay, will be asked for participation in the proposed study when their delirium has ended.
Inclusion criteria control group: All patients who are acutely admitted (within 3 days) to the Department of Geriatrics and did not developed a delirium during their hospital stay.
Exclusion criteria
Exclusion criteria:
(1) A delirium at time of assessment
(2) A Mini-Mental State Exam score below 18, indicating severe cognitive
problems
(3) Patients not capable of giving informed consent
(4) Sight and/or hearing impairments
(5) A palliative policy
(6) Inability to speak, read, write or understand Dutch
(7) Patients who are not testable according to physicians/nurses
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL26507.028.08 |