The aim of the study is to evaluate the effect of stroke volume variation on different parameters of peripheral perfusion. Additionally the relationship between these parameters will be studied.
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
septisch en niet-septische shock
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The primary study parameter is the peripheral perfusion assessed by 1) laser
doppler flowmetry, 2) sidestream dark field imaging, 3) near infrared
spectroscopy, 4) photopletysmography.
Secondary outcome
Not applicable
Background summary
Intravenous administration of fluids is one of the cornerstones of treatment of
hemodynamically instable patients admitted to the intensive care. The aim of
fluid administration is improving tissue perfusion. The effect however is
mainly assessed by the increase of cardiac output and stroke volume. Currently
there is no clinical parameter which objectively evaluates the effect of fluid
administration on tissue perfusion. New techniques are available which are able
to assess tissue perfusion non-invasively. It is possible that one or more of
these parameters are capable to guide the fluid regime on the individual needs
of the patient based on the tissue perfusion.
Study objective
The aim of the study is to evaluate the effect of stroke volume variation on
different parameters of peripheral perfusion. Additionally the relationship
between these parameters will be studied.
Study design
The study will be carried out on the Intensive Care of the Erasmus Medical
Center and will be carried out as a single center intervention trial.
Intervention
The intervention is a passive leg raising maneuvre. The patient is placed in a
semi-recumbent position of 30 degrees. The passive leg raising is performed by
elevating the patient's legs by 30 degrees and by simultaneously transferring
the trunk from the semi-recumbent position to a horizontal position.
Transferring the patient to the passive leg raising position transfers venous
blood from the legs to the intrathoracic compartment and increases cardiac
preload.
Study burden and risks
The passive leg raising and measurements of peripheral perfusion will not
involve risks for the subject. The passive leg raising is temporarily and the
effects will not affect the subject negatively. The methods to measure
peripheral perfusion are based on light with harmless wavelengths. The
measurement probes will only slightly make contact with the skin and the
sublingual area of the subject. The duration of the study for the individual
patient is 15 minutes.
's Gravendijkwal 230
3015 CE Rotterdam
Nederland
's Gravendijkwal 230
3015 CE Rotterdam
Nederland
Listed location countries
Age
Inclusion criteria
Patients admitted to the intensive care with circulatory failure due to septic or non-septic shock.
Age > 18 years.
Use of invasive hemodynamic monitoring to assess cardiac output and strokevolume.
Exclusion criteria
Admittance with cerebral disorders.
Elevated intra-abdominal pressure.
Ischemia of the lower extremities
Decreased left ventricular function
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL27359.078.09 |