1) to assess whether in-vivo abnormalities related to amyloid-β depositions can be detected in the cortical grey matter of AD patients using a 7T MRI system, and 2) to assess whether these abnormalities can be quantified. The future goal is…
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
hersenaandoening
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The main study parameter will be a qualitative measure of the presence of
distinct hypointense cortical foci and an inhomogeneous aspect of the cortex.
Secondary outcome
The secondary study parameter will be a quantitative measure of susceptibility
related changes in the cortex.
Background summary
One of the histological hallmarks of Alzheimer*s disease (AD) is the presence
of amyloid plaques. Previous research showed that granular hypointense foci in
the cortical grey matter and an inhomogeneous cortex could be visualized in
post mortem human brain specimens with AD in clinically acceptable acquisition
times. These abnormal features were ascribed to the presence of amyloid
depositions, and are probably based on the susceptibility artefacts caused by
iron which co-localizes with amyloid depositions.
Study objective
1) to assess whether in-vivo abnormalities related to amyloid-β depositions can
be detected in the cortical grey matter of AD patients using a 7T MRI system,
and 2) to assess whether these abnormalities can be quantified. The future goal
is to be able to use 7T MRI as a diagnostic tool for the in-vivo diagnosis of
Alzheimer*s disease.
Study design
Observational cross sectional case-control study.
Study burden and risks
This is a non-therapeutic group relatedness study. In order to achieve the aim
of the study AD patients are needed, because of the high likelihood of the
presence of amyloid plaques. The study consists of one single MRI scan that has
no consequences for the health of the participants. MRI contra-indications will
be carefully investigated per subject to minimize the risks. Burden will be
kept to a minimal by using a short MRI protocol and selecting only those
subjects who felt comfortable during their previous MRI scan.
Albinusdreef 2
2300 RC Leiden
Nederland
Albinusdreef 2
2300 RC Leiden
Nederland
Listed location countries
Age
Inclusion criteria
- Diagnosed with probable Alzheimer's disease
- Diagnosed as memory complainer
- Capable of giving informed consent
Exclusion criteria
- Contra-indication to MRI scanning:
• Claustrophobia
• Pacemakers and defibrillators
• Nerve stimulators
• Intracranial clips
• Intraorbital or intraocular metallic fragments
• Cochlear implants
• Ferromagnetic implants
• Hydrocephaluspump
• Intra-utrine device
• An iron wire behind the teeth
• Permanent make-up
• Tattoos above the shoulders
- MMSE < 19 points
- Severe physical restrictions (completely wheelchair dependent)
- Fear or problems during the 3T MRI scan
- Age above 90
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL27259.058.09 |