The present study aims to investigate several cognitive and emotional factors associated with chronicity of alcohol dependence.
ID
Source
Brief title
Condition
- Psychiatric disorders NEC
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Behavioural data and Blood Oxygenated Level Dependent (BOLD)-response, recorded
using fMRI, will be measured. These, and behavioural data are correlated with
chronicity of alcohol dependence in order to investigate weather differences in
several cognitive and motivational activities underlie the differences in
chronicity of alcohol dependence.
Secondary outcome
nvt
Background summary
Neurophysiological changes in the brain are important in the development and
maintenance of disorders in alcohol use, like alcohol dependency (AD). AD is
characterized by abnormal functioning of several cortical and subcortical brain
areas. This dysregulation is characterized by increased responsiveness to
stimuli that have become associated with the drug through conditioning. Whether
this enhanced responsiveness to drug cues is associated with abnormal
reactivity to emotional stimuli in general is poorly understood. The present
substudy will examine the neurophysiological pathways of AD in a large
high-risk cohort of 2981 persons with depressive and/or anxiety disorders as
part of the Netherlands Study of Depression and Anxiety (NESDA). Functional
magnetic resonance imaging (fMRI) will be performed in patients with alcohol
dependence of varying chronicity. Processing of emotional and motivational
information as well as cognitive control will be examined and compared between
groups. We expect that in less chronic AD mostly deficiencies in rewarding and
motivation will be visible, while in the more chronic AD deficiencies will be
mainly present in cognitive control and habit formation.
Study objective
The present study aims to investigate several cognitive and emotional factors
associated with chronicity of alcohol dependence.
Study design
Cross-sectional experimental design using MRI-techniques.
Intervention
A part of the patients will be asked not to drink any alcohol 24 hours prior to
the research.
Study burden and risks
Participants will visit the AMC (location of the scanner) once. This visit will
last maximally 2 hours. Forms and questionnaires will be filled in. Four
behavioural tasks will be perfomed during the MRI scan session of approximately
70 minutes. All respondents are asked not to drink alcohol or use drugs 24
hours prior to the experimental day. A urine sample and an alcohol-breath test
will be taken. Blood pressure and heartbeat will be measured with an automated
blood pressure monitor.
v/d Boechorststraat 7
1081 HV Amsterdam
NL
v/d Boechorststraat 7
1081 HV Amsterdam
NL
Listed location countries
Age
Inclusion criteria
Per group: (I) current DSM-IV diagnosis alcohol dependency and 6 month DSM-IV diagnosis of depression and/ or anxiety disorder; (II) 6-month DSM-IV diagnosis depression and/or anxiety disorder; (III) No DSM-IV psychiatric disorder
Exclusion criteria
(a) the use of psychotropic medication except for selective serotonin reuptake inhibitors in stable dosage, (b) major internal or neurological disorder, (c) known contra-indications for MR investigations, such as the presence of metal objects (e.g. pacemaker, arteriovenous clips), or claustrophobia
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL26065.029.08 |