In this investigation we want to regain more insight in the cardiovascular risk profile of RA patients. Also we want to find out which patients should have more attention concerning their cardiovascular risk profile and probably therapy for…
ID
Source
Brief title
Condition
- Other condition
- Arteriosclerosis, stenosis, vascular insufficiency and necrosis
Synonym
Health condition
gewrichtsaandoeningen
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
-Small artery elasticity
-Intima media thickness
-Advanced glycation end products in de huid
Secondary outcome
- soluble AGE receptor( s-RAGE)
- endothelial activation markers such as VCAM, vWF, trombomoduline
Background summary
In patients with reumatoid arthritis an increased cardivascular morbidity and
mortality is present.
We hypothesize that in achieving disease remission also the cardiovascular risk
will decrease. We will inverstigate this using the following parameters:
-Intima media thickness
-Small artery elasticity
-Advanced glycation end products in the skin.
Study objective
In this investigation we want to regain more insight in the cardiovascular risk
profile of RA patients. Also we want to find out which patients should have
more attention concerning their cardiovascular risk profile and probably
therapy for traditional risk-factors such as hypercholesteolemia and
hypertension.
Study design
We willen 60 patienten includeren met recent gediagnosticeerde RA, die nog niet
behandeld zijn en bij hen de uitgangswaarden bepalen wat betreft de
surrogaatmarkers voor cardiovasculaire ziekte. Na een jaar en na twee jaar
herhalen we de metingen.
60 patiewnts will have to be included with recent onset reumatoid arthritis. In
these patients the surrogate markers for atherosclerosis (intima media
thickness, small artery elasticity and AGE accumulation in the skin) will be
assessed before start of the treatment and after one and two years.
Study burden and risks
Measurement of IMT/PWA and AGE's every year during 1,5hrs. A total amount of
three measurements in two years gives a total of 4,5hrs
hanzeplein 1, postbus 30001
9700 RB Groningen
Nederland
hanzeplein 1, postbus 30001
9700 RB Groningen
Nederland
Listed location countries
Age
Inclusion criteria
fulfill the ACR criteria for RA
symptoms< 1 year
age >18 years
not previously received disease modifying antirheumatic drugs.
Exclusion criteria
pregnancy
diabetes
renal impairment( eGFR>60ml/min)
recent surgery
myocardial infarction or sepsis in the last three months
Design
Recruitment
Medical products/devices used
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL26277.042.08 |