The primary objective of this sutdy is to further investigate attention and MSI in adolescents with ASD. To do so, the following tasks will be administered. Task 1 Clock task: multisensory integration and the effect of sound on the velocity of the…
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Brief title
Condition
- Psychiatric disorders NEC
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Task 1. the main parameter is task 1 is visual latency; the difference between
the reported and the actual time on the target clock. This parameter is
calculated for each trials in each condition. To examine the "pure" effect of a
sound, difference scores between the vision-only baseline and the sound
conditions are calculated.
Task 2: the speed of shift attention is the main paramtere in this task. This
speed is calculated by comparing Reaction times (RTs) between valid and
non-valid trials. The RTs are corrected for accuracy.
Task 3: The main parameter in task 3 is the Just Noticeable Difference (JND)
for visual temporal order. The JND reflects the smallest time difference (in
milliseconds) between two flashes that participants need to perceive correct
visual temporal order.
Task 4: main parameter is RT of the visual search. The RT refletcs the time to
respond to the visual target from the search display onset. RTs are corrected
for acuracy.
Secondary outcome
not applicable
Background summary
In our previous study we examined visual temporal prossing and multisensory
integration (MSI) of sound and vision in adolescents with Autism Spectrum
Disorder (ASD). The main result of this study was that the effect of the sound
was much bigger for ASDs than for the typically developing adolescents (TDs).
This enhanced temporal ventriloquist effect (performance of visual temporal
order improves if sounds are presented at the right timing) demonstrates that
ASDs do not suffer from a generalized deficit in MSI, as they profited more
from sound than less. Compared to TDs though, ASD were impaired in judging the
temporal order of two flashes if the flashes were presented in silence. These
resuls can be explained by an attentional acocunt where ASDs suffer from slow
attentional shifting that is improved by sound. In our next study we would like
to further investiagte this idea.
Study objective
The primary objective of this sutdy is to further investigate attention and MSI
in adolescents with ASD. To do so, the following tasks will be administered.
Task 1 Clock task: multisensory integration and the effect of sound on the
velocity of the attentional shift
Task 2 Crossmodal cueing: crossmodal integration and the ability to engage and
shift attention
Task 3 Visual TOJ: temporal ventriloquism
Task 4 Pip & Pop: effect of sound on attention (search behavior and MSI)
Study design
Design task 1: The clock task consist of 4 conditions in which sound is
presented before or after the visual target; no sound, 0ms, -100ms and +100ms.
There are 4 clocklocations for the target to show up. This results in 16 unique
trials which are randomly presented in 3 blocks of 80 trials each.
Design taks 2: Cues are presented at 100 or 800ms before the target. This cue
can be visual or auditory and is presented left or right of fixation. There are
2 targetlocations (up or down). These 16 unique trials are 10 ten times
randomly presented in 2 blocks of 80 trials
Design task 3: The VTOJ task has five conditions; a no sound condition and 4
condities with audiovisual delays at 0ms, 100ms, 200ms, and 300ms. The visual
flashes are presented at 8 SOAs ranging from -133 ms to +133 ms. This results
in 40 unique trials, each randomly presented 16 times in four blocks of 160
trials each.
Design task 4: this task consist of 2 conditions in which 6 or 12 stimuli with
or without sound are presented. These 4 unique trials are 20 times presented in
2 blocks of 40 trials.
Study burden and risks
As far as we can consider there are no risks related to this study. Therefore
we do not foresee any difficulties that could lead to any medical, mental or
physical problems. There is a mental load, but this is minimized by conducting
the experiments on two different days and each experiment can be stopped for a
break. Participation in this study implies that one contributes to the
development of (fundamental) knowledge about attentional issues and
multisensory processing within the temporal domain as a possible underlying
deficit in social interaction and communication in children (and people in
general) with autism. For the future, the outcome of this study could have
practical and clinical implications for the treatment of autism. This study is
group-related, because it could not be conducted without the participation of
adolescents with autism (all belonging to one group). We would like to acquire
more knowledge on differences in (multi)sensory processing and attentional
issues between autistic and healthy adolescents and the suggested deficits in
autistics, present at childhood age. Therefore, we include autistic adolescents
in our study to examine whether multisensory temporal deficits are indeed a
core problem and whether these deficits are manifest at that age.
Warandelaan 2
Postbus 90153, 5000 LE Tilburg
NL
Warandelaan 2
Postbus 90153, 5000 LE Tilburg
NL
Listed location countries
Age
Inclusion criteria
- Presence of an autism disorder according to the DSM-IV criteria for autism, diagnosed by a professional clinical team, (possible added with an score of the Autisme Beoordelingslijst (ABL) which is administered by certified raters)
- Age between 14 and 23 years
- Normal hearing and normal or corrected to normal vision
- Written consent by parent or caregiver and/or adolescent
Exclusion criteria
- Evidence of a serious medical, neurological or psychiatric illness (apart from autism), seizure disorders, trauma or a use of medications affecting the nervous system
- color blindness;Individuals in the control group are excluded if there are concerns about:
- learning disabilities
- mental retardation
- language delays
- head trauma
- psychiatric conditions
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL32533.008.10 |