Primary Objective: 1. Are the effects of conscious and unconscious priming effects on selfagency different in schizophrenia as compared to health?2. What are the functional and structural neural substrates underlying conscious and unconscious…
ID
Source
Brief title
Condition
- Schizophrenia and other psychotic disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Study 1:
- Performance of patients on selfagency paradigm compared to controls (off
line, i.e. no MRI scanner))
Study 2:
- Difference between patients and controls in volume (sMRI) or density (VBM) in
selfagency related brain areas.
- Finding the areas in healthy controls that are involved when attributing
selfagency to one*s own actions using the BOLD signal (fMRI)
- Difference between patients and controls in brain activation (BOLD) while
doing a selfagency task
Secondary outcome
Baseline values or parameters which might intervene with the main study
parameter (age, gender, years of education, symptoms, level of functioning,
medication intake)
Background summary
The conscious experience of selfagency, i.e. the feeling that one causes one*s
own actions and their outcomes, is fundamental to human self-perception. Recent
research suggests that there are two routes to the experience of selfagency:
(1) a conscious one, deriving from our intentions to produce a specific
action-outcome; and (2) an unconscious one, following from enhanced
pre-activation of outcome information outside of awareness (e.g., by means of
subliminal priming). In both cases, people experience selfagency over behavior
when outcome representations that are primed prior to action execution match
with the actual outcome.
Thus far, previous research mainly addressed the cognitive processes underlying
the conscious and unconscious effects on selfagency in healthy people. However,
the anatomical underpinnings of the authorship ascription process remain a
mystery. The present proposal focuses on this core issue by examining
structural and functional neural correlates of conscious and unconscious
processes underlying the selfagency in health and in schizophrenia - a
psychiatric disorder strongly associated with a disturbed sense of agency.
Study objective
Primary Objective:
1. Are the effects of conscious and unconscious priming effects on selfagency
different in schizophrenia as compared to health?
2. What are the functional and structural neural substrates underlying
conscious and unconscious priming effects on selfagency in health?
Study design
case-control design, comparing patients with schizophrenia and matched healthy
individuals
Study burden and risks
A magnetic resonance imaging (MRI) scan session of approximately 60 minutes
will be performed: MRI is a non-invasive technique, so there is no need for
special preparation for the subject. There are no known risks associated with
the MRI acquisition and the data are solely used for research purposes.
However, structural cerebral pathology may be noticed. If medical treatment is
indicated, the subject will be notified.
No immediate benefits are to be expected from participation in this study for
the subjects. In the long run, increased understanding of the etiology and
pathophysiology of psychiatric illness in general and schizophrenia in
particular, may contribute to diagnosis, early detection and/or prediction of
treatment outcome.
Heidelberglaan 100
3584 CX utrecht
NL
Heidelberglaan 100
3584 CX utrecht
NL
Listed location countries
Age
Inclusion criteria
Patients:
-Do have a DSM-IV diagnosis of schizophrenia
-Do not chronically use medication, other than psychiatric medication
-Give written informed consent
-Do not have a major medical history
-Are not in an acute psychotic episode
Healthy subjects:
-Do not have a psychiatric history
-Do not have a first-degree family member with a psychiatric illness with psychotic features.
-Do not chronically use medication
-Give written informed consent
-Do not have a major medical history;Specific for the imaging study:
Subjects have to satisfy the following criteria in order to participate in the study:
-Do not have a pacemaker
-Do not have metal materials in the head (except for dental braces)
Exclusion criteria
All subjects:
-Drug or alcohol abuse over a period of six months prior to the experiment
-History of closed-head injury
-History of neurological illness or endocrinological dysfunction
-Unable to give consent;Specific for the imaging study:
-Ferrous objects in or around the body (e.g. braces, glasses, pacemaker, metal fragments)
-Claustrophobia
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
Register | ID |
---|---|
CCMO | NL32474.041.10 |