To evaluate the prognostic value of the EEG, including quantitative EEG features, TMS and SSEP after out-of-hospital cardiac arrest.
ID
Source
Brief title
Condition
- Encephalopathies
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The main study parameters are the EEG trend curves obtaind by extracting
quantitative EEG features from the raw EEG data, as well as the TMS and SSEP
responses measured during the first days after hospital admission. These
parameters will be compared with the neurological outcome of the patient
measured on the Glasgow-Pittsburgh Cerebral Performance Categroy (CPC) score
and EQ-6D questionnaire.
Secondary outcome
The EEG, TMS and SSEP parameters measured after 1 and 3 months.
Background summary
Survival rate after cardiac arrest is poor. Neurologic recovery is determined
primarily by the extent of postanoxic encephalopathy (PAE). An early neurologic
prognosis could be very helpful in these PAE patients. Absence of short latency
somatosensory evoked potential (SSEP) has a good predictive value for poor
prognosis in these patients. However, its sensitivity is only moderate. Also
the electroencephalogram (EEG) has shown to correlate with the neurological
outcome of PAE patients. Nevertheless, it is still impossible to give an early
reliable prognosis for an individual patient. We hypothesize that the prognosis
in PAE patients could be improved with continuous EEG monitoring and the
addition of quantitative EEG features that can be extracted from the raw EEG
data. Hereby not only the absolute value of the quantitative EEG features could
be useful, but the trend of these features over the first days might be even
more interesting. Furthermore, by combining these EEG parameters with short
latency, as well as long latency SSEP measurements and the evaluation of the
transcranial magnetic stimulation (TMS) response, additional improvement in
prognosis may be feasible. To test this hypothesis we want to give PAE patients
admitted to the ICU for hypothermia treatment TMS stimuli once a day and do a
follow-up study in 20 of these PAE patients with a good neurological outcome.
Study objective
To evaluate the prognostic value of the EEG, including quantitative EEG
features, TMS and SSEP after out-of-hospital cardiac arrest.
Study design
Prospective observational study
Study burden and risks
We will perform a TMS measurement once a day during the first days (day 2 - day
5) of admission to the ICU. Patients with a good neurological outcome will be
asked to participate in the follow up study. In this follow-up study the
patients have to visit the hospital twice (1 and 3 months after their admission
to the ICU) for an EEG, TMS and SSEP measurement. All measurements are
non-invasive, will only produce minor discomfort to the patient and do not have
associated risks.
Postbus 217
7500 AE Enschede
NL
Postbus 217
7500 AE Enschede
NL
Listed location countries
Age
Inclusion criteria
- Cardiac arrest
- Admitted to the ICU for therapeutic hypothermia
- Age above 18 years
- Obtained informed consent
Exclusion criteria
- Terminal illness
- Psychoactive or anticonvulsive medication
- Known history of a neurologic disease (stroke, parkinson, epilepsy)
- Known history of brain surgery or severe brain trauma
- Known history of drug or alcohol abuse
- Severe neuropathy in the arms
- Not having two arms
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL32007.044.10 |