The aim of the present study is to establish intero-interoceptive fear conditioning in healthy participants in a differential conditioning paradigm. We want to make use of *real* interoceptive conditioned stimuli: a low respiratory load and small…
ID
Source
Brief title
Condition
- Anxiety disorders and symptoms
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The main study outcome are the subjective reports of fear (VAS-F) during the
test-phase.
Secondary outcome
The secondary outcomes are the self reports of physical symptoms and the
physiological measurements (respiration rate, tidal volume) that are assessed
during the test-phase.
Background summary
More than 20% of the general population experience a panic attack once in their
lives; however, only a minority goes on to develop panic disorder. The alarm
theory tries to explain the etiology of panic disorder through interoceptive
conditioning. To date studies concerning panic disorder and interoceptive
conditioning are limited.
Study objective
The aim of the present study is to establish intero-interoceptive fear
conditioning in healthy participants in a differential conditioning paradigm.
We want to make use of *real* interoceptive conditioned stimuli: a low
respiratory load and small infusions of pentagastrin. CO2-enriched air is used
as unconditioned stimulus.
Study design
This study involves a double-blinded randomised design
Intervention
The use of pentagastrin/placebo or inspiratory load/placebo.
Study burden and risks
There are no risks associated with this study. During CO2-inhalation
participants can feel symptoms of arousal and fear, but these are of short
duration and are harmless. There are no long term effects of CO2-inhalation.
There are also no risks associated with the injections or with the inspiratory
loads. In our study we will only use a very small dosage of pentagastrin and
inspiratory load, which will only causes feelings of discomfort/ resistance in
healthy volunteers. Both will only be administrated to healthy volunteers. The
burden for participants is rather low. Screening faze will take 30 minutes. The
duration of the experiment is 45 minutes and there is a pause of 30 minutes.
The experiment consists of two visit to the laboratory.
P.O. Box 88
6200 AB Maastricht
NL
P.O. Box 88
6200 AB Maastricht
NL
Listed location countries
Age
Inclusion criteria
A good physical condition and age between 18-65 years
Exclusion criteria
A psychiatric disorder- history of pulmonary disease (including asthma and lung fibrosis)- history of cardiovascular disease (including cardiac failure, suspicion of infarct, cardiomyopathy, TIA, angina pectoris, arrythmias)- hypertension- personal or familial history of cerebral aneurysm- pregnancy- epilepsy- psychotropic medication use- use of α2- or β-blockers- idiosyncratic response to pentagastrin- if participants refuse insight in deviant findings.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
In other registers
| Register | ID |
|---|---|
| CCMO | NL32415.068.10 |
| Other | nog niet gekregen |
| OMON | NL-OMON20198 |