To investigate the effects of three different methods of finding a suitable recording site for CMAP and three different electrode sizes on CMAP amplitude and its reproducibility
ID
Source
Brief title
Condition
- Muscle disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
CMAP parameters (latency, duration, amplitude and area of distally evoked
CMAPs) as well as conduction parameters (motor nerve conduction velocity
(MNCV), and the percentile changes of amplitude, duration and area over the
length of nerve) described as means with standard deviation (SD), as well as
with the coefficient of variation (CV).
Secondary outcome
not applicable
Background summary
Because of large interindividual variability and poor reproducibility, the
Compound Muscle Action Potential (CMAP) as an estimate of the functional motor
units has a relatively poor diagnostic validity. Improving reproducibility and
reducing site-induced variability by defining the most optimal approach for
measuring CMAP parameters will lead to improved accuracy and diagnostic yield
of nerve conduction studies.
Study objective
To investigate the effects of three different methods of finding a suitable
recording site for CMAP and three different electrode sizes on CMAP amplitude
and its reproducibility
Study design
Repeated comparison of CMAP recording methods
Study burden and risks
Very little. Only 2 short-lasting visits. CMAP measurements could be a bit
painful, but usually this is not the case.
Albinusdreef 2
2300 RC Leiden
Nederland
Albinusdreef 2
2300 RC Leiden
Nederland
Listed location countries
Age
Inclusion criteria
aged between 18 and 50
Exclusion criteria
evidence of diseases of or predisposing to peripheral nerve damage of the leg
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL32319.058.10 |