To test the gene by stress interaction model in humans by investigating how genetic variation alters neural responses to environmental stress.
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
gezonde deelnemers
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Functional Magnetic Resonance Imaging (fMRI)
Secondary outcome
Salivary levels of cortisol and alpha-amylase
Self-report questionnaires
Psychophysiological recordings (electrodermal activity, breathing rate, heart
rate, blood pressure, pupil diameter)
Background summary
Genetic variation in the corticosteroid and noradrenergic systems affects the
acute response to environmental stressors. An animal model suggests that this
could be mediated by genetically determined sensitivity of the brain to
environmental stress.
Study objective
To test the gene by stress interaction model in humans by investigating how
genetic variation alters neural responses to environmental stress.
Study design
A counterbalanced, crossover design.
Study burden and risks
The risk associated with participation can be considered negligible and the
burden can be considered minimal. No pharmacological nor (otherwise) invasive
interventions are applied. Participants will undergo two MRI sessions including
standard fear conditioning using mild electrical stimulation to the fingers.
Kapittelweg 29
6525 EN
NL
Kapittelweg 29
6525 EN
NL
Listed location countries
Age
Inclusion criteria
Male, between 18 and 45 years of age, predominant right-handedness.
Exclusion criteria
History of psychiatric treatment or current psychiatric treatment, history of neurological treatment or current neurological treatment, history of endocrine treatment or current endocrine treatment.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL31285.091.10 |