Evaluate the effect of intrathoracic pressure on right ventricular function in healthy subjects.
ID
Source
Brief title
Condition
- Respiratory disorders NEC
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Ejaction Fraction
Stroke Volume
Esophageal pressure
Pulsatility of Pulmonary Artery
Secondary outcome
not applicable
Background summary
In chronic obstructive pulmonary disease (COPD) high intrathoracic pressure may
develop due to airflow limitation and hyperinflation. The effect of high
intrathoracic pressure on pulmonary artery pressure and right ventricular
function is not well known.
(see also dossier: NL30766.029.10)
Study objective
Evaluate the effect of intrathoracic pressure on right ventricular function in
healthy subjects.
Study design
Observational
High intrathoracic pressure during expiration in healthy subjects will be
created by expiration through a adjustable water column, during cardiac
Magnetic Resonance Imaging
The esophageal pressure, as a surrogate of intrathoracic pressure, while
breathing against the different levels of water will be measured after the
cMRI.
Study burden and risks
No risks known for this study
Only burden is this study is the esophageal balloon for pressure measurements
Postbus 7057
1007 MB Amsterdam
Nederland
Postbus 7057
1007 MB Amsterdam
Nederland
Listed location countries
Age
Inclusion criteria
Healthy subjects
> 18 yrs
Exclusion criteria
Smoking
Cardiovascular disease
Pulmonary disease
Systemic Hypertension
Claustrophobia
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL30803.029.10 |