To study the application of fMRI for the detection of BAT perfusion.
ID
Source
Brief title
Condition
- Other condition
- Metabolism disorders NEC
Synonym
Health condition
obesitas
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Validity of fMRI for the study of BAT activity.
Secondary outcome
nvt
Background summary
The problem of obesity is increasing in the western world. Brown fat can have a
possitive effect on the human energy balance and body weight regulation.
Currently BAT is detected by PET/CT. With PET/CT it is not possible to study
BAT dynamics. WIth the use of fMRI it is in principle possible to study the
dynamics of blood perfusion in BAT.
Study objective
To study the application of fMRI for the detection of BAT perfusion.
Study design
Validation study comparing BATactivity with PET/CT and BAT blood perfusion by
fMRI during cold exposure.
Study burden and risks
The radiation dose is 2.8 mSv. This is considered a low risk. The other
measurements are hardly (DXA scan) or non invasive.
Postbus 616
6200 MD Maastricht
NL
Postbus 616
6200 MD Maastricht
NL
Listed location countries
Age
Inclusion criteria
• Healthy adults
• BMI: 18-30 kg/m2 (lean)
• Gender: Male and female
• Age: 18-30 years
Exclusion criteria
• Diabetes Mellitus
• Pregnancy
• Medication: use of Beta-blockers
• Contra-indications to MRI and/or therapeutic radiation
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL30699.068.10 |