To study the correlation between salivary T and (measured and calculated) serum free T.
ID
Source
Brief title
Condition
- Endocrine disorders of gonadal function
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
concentration of testosterone in saliva and free testosterone concentration in
serum
Secondary outcome
not applicable
Background summary
Free testosterone (fT) levels reflect the physiological actions of the hormone.
However, determination of free testosterone concentrations is cumbersome. So
for diagnostics purposes total testosterone (tT) in serum is measured as a
substitute. An alternative is salivary T, which is believed to reflect the fT
concentration. Saliva measurements have great advantages: sample collection is
minimally invasive and a practical alternative for (sequential) measurements of
serum testosterone. Recent technical developments enables us to measure T in
different matrices with great sensitivity and in small sample volumes. A
salivary and a serum T assay has been developed using liquid chromatography *
tandem mass spectrometry (LC-MS/MS) to investigate the correlation between fT
and salivary T, so that salivary T can be assessed in future studies.
Study objective
To study the correlation between salivary T and (measured and calculated) serum
free T.
Study design
The levels of testosteron in saliva and (measured and calculated) serum free
testosterone will be compared.
Study burden and risks
One blood sample via venapucture and one saliva sample will be taken from
experimental subjects.
De Boelelaan 1118
1081HZ Amsterdam
NL
De Boelelaan 1118
1081HZ Amsterdam
NL
Listed location countries
Age
Inclusion criteria
age >18 yrs
Exclusion criteria
none
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL30102.029.09 |