The aim of the study is to observe which of the microcirculatory parameters characterizes the septic patients and to investigate which of these alterations are related to mortality and organfailure. Additionally the changes over time, the…
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
ernstige sepsis en septische shock
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The primary study parameter is the peripheral perfusion measured at the skin of
the extremities and the sublingual microcirulatory perfusion.
Secondary outcome
not applicable
Background summary
In patients admitted to the intensive care unit with severe sepsis,
microcirculatory alterations are frequently observed. These microcirculatory
alterations are associated with a poor prognosis especially when these
alterations do not improve in time. There are several ways to measure
microcirculatory perfusion, peripherally on the skin of the extremities or in a
more central compartment i.e. sublingually. It remains unclear which of these
parameters characterizes the microcirculatory perfusion of the septic patient .
Additionally it is not known which of the perfusion parameters are related to
outcome.
Study objective
The aim of the study is to observe which of the microcirculatory parameters
characterizes the septic patients and to investigate which of these alterations
are related to mortality and organfailure. Additionally the changes over time,
the relationship with systemic hemodynamic parameters and the interrelationship
between the several parameters of microcirculatory perfusion will be studied.
Study design
The study will be carried out on the Intensive Care of the Erasmus Medical
Center and will be carried out as a single center observational study.
Study burden and risks
The measurements of peripheral perfusion and sublingual microcirculation will
not involve risks for the subject. The methods to measure peripheral perfusion
are based on light with harmless wavelengths. The measurement probes will only
slightly make contact with the skin and the sublingual area of the subject.
In the future patients could benefit from the results, by optimizing the
treatment based on individual parameters of microcirculatory perfusion.
's Gravendijkwal 230
3015 CE Rotterdam
NL
's Gravendijkwal 230
3015 CE Rotterdam
NL
Listed location countries
Age
Inclusion criteria
Patients admitted to the intensive care with organ dysfunction or circulatory failure due to severe sepsis or septic shock. Age > 18 years.
Exclusion criteria
Severe vascular pathology. Circumstances making it impossible to perform sublingual measurements, like bleeding of the oral cavity
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL30450.078.10 |