1) To evaluate absolute myocardial blood flow and resistance over time in the acute and sub-acute phase of myocardial infarction2) To correlate these parameters to preservation of left ventricular function and long-term outcome.
ID
Source
Brief title
Condition
- Cardiac disorders, signs and symptoms NEC
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Absolute coronary and myocardial blood flow and absolute resistance after
successful primary PCI amd after 3-5 days.
Secondary outcome
- Left ventricular function determined by echocardiography immediately after
successful primary PCI and after 3-5 days.
- Viability of the myocardium (or absence of viability) determined by MRI 3-5
days after the acute phase.
Background summary
Although microvascular dysfunction (no reflow) is often present after acute
myocardial infarction, little is known about differences in different patients
and about recovery in the first days after myocardial infarction. Even less is
known about the consequences for left ventricular function on the long-term.
Study objective
1) To evaluate absolute myocardial blood flow and resistance over time in the
acute and sub-acute phase of myocardial infarction
2) To correlate these parameters to preservation of left ventricular function
and long-term outcome.
Study design
Open, mono-center, unblinded study.
Study burden and risks
1) After successful primary PCI, the patients stays in the catheterization
laboratory for another 20 minutes to perform the measurements of
blood flow and resistance.
2) After 3-5 days, a second catheterization will be performed with the
physiologic measurements. In approximately 50% of the patients the is an
extra investigation; for the other 50%, this exam is replacing the
catheterization which would have been performed otherwise after 2 to 3
weeks.
3)
4)
5)
Michelangelolaan 2
5623 EJ Eindhoven
NL
Michelangelolaan 2
5623 EJ Eindhoven
NL
Listed location countries
Age
Inclusion criteria
Acute myocardial infarction presenting at the cath lab within 12 hours of onset of pain.
Exclusion criteria
Instability of the patient after primary percutaneous coronary intervention.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL37938.060.11 |