The main objective of this study is to obtain normal values for high-resolution manometry. The second objective is to investigate the inter- and intra-individual variability of the measured parameters.
ID
Source
Brief title
Condition
- Gastrointestinal motility and defaecation conditions
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The main parameters that are important in routine clinical manometry:
propagating velocity, lower oesophageal sphincter (LES) pressure and LES nadir
pressure, the proximal and distal contraction propagation velocity and proximal
and distal oesophageal peristaltic amplitude.
Secondary outcome
Interindividual and intraindividual variability.
Background summary
Since its introduction in the 1950s oesophageal manometry has been the mainstay
in the evaluation of oesophageal motility disorders. With conventional
manometry pressures are usually measured at 5 cm intervals in the oesophagus
and its sphincters. High-Resolution manometry (HRM) is a relatively new tool in
the evaluation of oesophageal motility and can be regarded as a technical
improvement over conventional manometry. Compared to conventional manometry,
the catheter itself contains more sensors and offers the possibility of
studying peristalsis at 1-cm intervals in the entire oesophagus. In addition,
pseudo 3D topographic plots or colour plots can be made, and this facilitates
the interpretation of the results. In analysing patients with oesophageal
motility disorders, is has been suggested that HRM improves understanding of
the precise pathophysiologic mechanism. In particular, in patients with
symptoms of dysphagia in which endoscopy and conventional manometry has
provided no explanation, HRM might be useful as it can hopefully provide a
better explanation for the symptoms, for example by revealing a localized
motility defect causing stasis of the swallowed bolus.
However, the obtained large data sets, gathered with HRM, constitute also its
limitation in widespread clinical implementation. Mainly, what is to be
regarded *normal* in the new paradigm is of particular importance since without
normal values clinical interpretation of measurements of patients is not
possible.
In addition, the inter- and intra-individual variability of the parameters used
is not known.
Study objective
The main objective of this study is to obtain normal values for high-resolution
manometry. The second objective is to investigate the inter- and
intra-individual variability of the measured parameters.
Study design
observational study
Study burden and risks
Participants will undergo stationary oesophageal high-resolution manometry
(HRM). HRM is a routine investigation at our department. No specific risk is
associated with this investigation.
Heidelberglaan 100
3508 GA Utrecht
Nederland
Heidelberglaan 100
3508 GA Utrecht
Nederland
Listed location countries
Age
Inclusion criteria
Written informed consent
Age above 18 years
No upper gastrointestinal symptoms
Exclusion criteria
Surgery of the gastrointestinal tract
Absence of informed consent
Gastrointestinal symptoms
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL25991.041.08 |