Our overall aim is to create a cost effective non-invasive method of pre-surgical assessment of language and memory function using MEG scanning. We propose a research project with the key objective to evaluate the effectiveness of a Dutch…
ID
Source
Brief title
Condition
- Seizures (incl subtypes)
- Nervous system, skull and spine therapeutic procedures
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Primary outcome is the establishment of a robust stimulation and analysis
protocol in a multi-centre study which may ultimately lead to a non-invasive
alternative to the Wada procedure for pre-surgical assessment of language and
memory function.
Secondary outcome
N/A
Background summary
To reduce the risk of aphasia or amnesia following surgical resection in
patients suffering from epilepsy and/or brain tumours it is necessary to
identify language and memory presentation pre-surgically. Of importance here is
to determine whether there is a dominant hemisphere with regards to language
and memory function. Currently, the gold standard for the evaluation of
lateralised language and memory mapping is the Wada procedure. Recent advances
in neuroimaging techniques however might provide us with opportunities to
replace this invasive procedure with a non-invasive and cost-effective
alternative to conduct pre-surgical assessment of language and memory function,
and in addition, help in the planning of grid implantations.
Study objective
Our overall aim is to create a cost effective non-invasive method of
pre-surgical assessment of language and memory function using MEG scanning. We
propose a research project with the key objective to evaluate the effectiveness
of a Dutch implementation of a language/memory stimuli and analysis protocol.
Study design
A MEG study using a silent verb generation and memory protocol.
Study burden and risks
Patients will undergo a completely non-invasive MEG recording, which will
require them to lie for approximately 30 minutes in a magnetically shielded
room, during which responses during a language and memory task, as well as
spontaneous activity, will be recorded. The MEG sensors do not touch the head,
but three separate coils are attached to the head to quantify head movement.
This procedure is not painful in any way, is not considered to be difficult or
stressing, and has negligible risks. In addition, besides the proposed study, a
routine clinical MEG and MRI protocol will be carried out, and, as part of the
pre-surgical evaluation, a Wada test.
De Boelelaan 1118
1081 HV Amsterdam
Nederland
De Boelelaan 1118
1081 HV Amsterdam
Nederland
Listed location countries
Age
Inclusion criteria
Age between 18 and 85
Has had, or will undergo, a Wada test
Will undergo a MEG and MRI scan as part of a pre-surgical evaluation
Written informed consent
Amendement: healthy volunteers for pilot study to test nre methodology
Exclusion criteria
Unable to undergo an MRI scan
Insufficient mastery of the Dutch language
Inability to communicate adequately
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL26907.029.09 |