To study the mechanisms by which T-cells can contribute to the defense against Aspergillus fumigatus.To study the role of the immune system and the role of Aspergillus antigens in the switch from a Th1 to a Th2 profile in patients with ABPA.
ID
Source
Brief title
Condition
- Allergic conditions
- Fungal infectious disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Frequency and cytokineprofile of Aspergillus-specific T-cells in blood and
broncho-alveolar lavage fluid
Presence and type of Aspergillus-specific antibodies
Secondary outcome
nvt
Background summary
Invasive aspergillosis is a common and life-threatening infectious complication
in patients with hematological diseases, in patients after stem cell
transplantation or solid organ transplantation and in patients with the primary
immune deficiency Chronic Granulomatous Disease. It is known that patients with
granulocytopenia have an increased risk of invasive aspergillosis, but in
recent years there is increasing evidence that T-cells also play an essential
role in the defense against Aspergillus fumigatus.
Another patient group, patients with Allergic Bronchopulmonary Aspergillosis
(ABPA) exhibit an allergic overreaction to Aspergillus fumigatus. The
Aspergillus-specific T-cells in these patients have a Th2 profile. It is
unknown what the cause is of the switch from a Th1 to a Th2 profile.
Study objective
To study the mechanisms by which T-cells can contribute to the defense against
Aspergillus fumigatus.
To study the role of the immune system and the role of Aspergillus antigens in
the switch from a Th1 to a Th2 profile in patients with ABPA.
Study design
Observational mechanistic study
Study burden and risks
At one to three time points 50 ml of blood will be drawn, if possible during an
existing vena puncture. When a broncho-alveolar lavage is performed BAL-fluid
will be collected for this research project.
No benefit for the participants is expected, neither any negative effects.
Albinusdreef 2
2333 ZA Leiden
NL
Albinusdreef 2
2333 ZA Leiden
NL
Listed location countries
Age
Inclusion criteria
Diagnosis Invasive Aspergillosis or suspected for this diagnosis
Diagnosis allergic reaction to Aspergillus
Partner of patient with allergic reaction to Aspergillus
Exclusion criteria
< 18 year of age
Not able to get informed consent
Design
Recruitment
metc-ldd@lumc.nl
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL35939.058.11 |