The prevalence of anti-CCP in periodontitis patients.
ID
Source
Brief title
Condition
- Other condition
- Autoimmune disorders
Synonym
Health condition
parodontitis
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The prevalence of anti-CCP in periodontitis patients.
Secondary outcome
To analyse if there is an association of anti-CCP positivity with the severity
of periodontitis.
To analyze if the prevalence of anti-CCP in periodontitis patients differs in
smoking and non-smoking subjects.
Background summary
Studies have shown an association between periodontitis and rheumatoid
arthritis. The hypothesis is that inflammation of the gingiva also causes the
production of ACPA's (anti-CCP). Anti-CCP can be found in serum years before
patients with rheumatoid arthritis show the first signs of arthritis. We
therefore hypothesise that there is a higher prevalence of anti-CCP in patients
with periodontitis.
Study objective
The prevalence of anti-CCP in periodontitis patients.
Study design
All subject with periodontitis diagnosed in a periodontology clinic will be
asked to participate. An explanation about the meaning of anti-CCP positivity
will be given. The periodontologist will provide information about the
severitiy of periodontitis. A questionnaire will be obtained to acquire data
about the periodontal and rheumatoid condition of the patients. The anti-CCP
will be obtained by a finger-prick test. When this test shows anti-CCP
positivity, the subject will be asked to have further follow-up.
Study burden and risks
The finger-prick test will be performed at the periodontitis clinic. If
positive, subjects will be asked to join a seperat follow-up study. There are
no risks related to a finger-prick test.
Meibergdreef 9
1105 AZ
NL
Meibergdreef 9
1105 AZ
NL
Listed location countries
Age
Inclusion criteria
patients with periodontitis, age 18-80 years
Exclusion criteria
none
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL36349.018.11 |
| Other | NTR |