Comparison of the salivary cortisol response after a standardized exercise test between prepubertal heathy children and children with asthma.
ID
Source
Brief title
Condition
- Adrenal gland disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Primary study parameter is the cortisol reponse (salivary cortisol level 15
minutes after cessation of the test minus pre exercise slaviary cortisol level)
of the children with asthma compared to the cortisol repsonse of the healthy
children
Secondary outcome
Secundary study parameter: correlation between mornong (basal) salivary
cortiosl level and cortisol repsons
Background summary
We have demonstrated that children with asthma have a significantly lower
salivary cortisol level than healthy prepubertal children. The clincial
relevance of this finding is unknown. However, in healthy adults it was shown
that short term treatment with inhaled corticosteroids blunted the cortisol
response during acute exercise. To the best of our knowledge, the effect of
inhaled corticosteroids on the cortisol response in children with asthma is
unknown.
Study objective
Comparison of the salivary cortisol response after a standardized exercise test
between prepubertal heathy children and children with asthma.
Study design
The children will perform a standardized running test (20 meter shuttle run).
Before, immediately after, and 15 minutes after cessation of the test the
children will perform a lungfunction test and subsequently collect saliva by
chewing on a Salivette for one minute. The test will be repeated after a
minimum of one week.
Intervention
The children will perform a standardized running test (20 meter shuttle run
test) under supervison of a paediatric physiotherapist, and one of the
investigators. The children will be instructed to run for as long as possible
between two lines drawn 20 m apart at an increasing speed. A signal will
indicate the required running speed. The speed will be set at 8 km per hour (km
h*1) and increased by 0.5 km h*1 every minute. The children will be encouraged
to continue running until exhaustion. The test is ended if the child cannot
reach the line within the set time.
Study burden and risks
Omdat kinderen met stabiel astma in het dagelijks leven voortdurend lichamelijk
inspanning verrichten denken wij dat het gerechtvaardigd is om de kinderen
tijdens het onderzoek deze rentest te laten verrichten.
Children with stable asthma perform physical activities (sports, physical
exercise at school)
Henri Dunantweg 2
8934 AD
NL
Henri Dunantweg 2
8934 AD
NL
Listed location countries
Age
Inclusion criteria
prepubertal children with stable asthma
Exclusion criteria
Unstable asthma (additional use of bronchodilator in previous month and/or oral setroids in previous 3 months)
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL37156.000.11 |