The main objective is to investigate the effect of tidal volume, airway pressure, breathing frequency, interbeat interval of the heart, respiratory resistance and lung compliance on arterial pressure variation in healthy subjects. The secondary…
ID
Source
Brief title
Condition
- Vascular therapeutic procedures
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The main study parameter is arterial blood pressure variation.
Secondary outcome
The study parameters which are measured to investigate there influence on the
arterial pressure variations are:
o tidal volume
o airway pressure
o lung compliance
o breathing frequency
o interbeat interval
o thorax impedance
o stroke volume
o tilt angle
Background summary
In anesthesia and intensive care medicine, intravenous volume is often
administered to improve tissue oxygen delivery. Too little circulating volume
(hypovolemia) can cause inadequate organ perfusion with ischemia and organ
failure. On the other hand, too much circulating volume can cause pulmonary and
peripheral edema that contributes to further tissue injury and organ
dysfunction. The cardiovascular responses upon volume administration are
determined primarily by their effect on the central blood volume. In
mechanically ventilated patients, arterial pressure variations have shown to be
good indices to predict if a patient will benefit from intravenous volume
administration. However, in spontaneously breathing patients, arterial pressure
variations have shown to be less predictive.
Study objective
The main objective is to investigate the effect of tidal volume, airway
pressure, breathing frequency, interbeat interval of the heart, respiratory
resistance and lung compliance on arterial pressure variation in healthy
subjects. The secondary objective is to improve the value of arterial pressure
variation as a predictor for fluid responsiveness.
Study design
Observational. In the Laboratory for clinical cardiovascular physiology, blood
pressure (BP), Stroke volume (SV), heart rate (HR), cardiac output (CO), tidal
volume, airway pressure and flow are evaluated under conditions of simulated
normovolemia (supine resting position) and graded hypovolemia (simulated by
passive 30 and 70 degrees head-up tilt positions).
Study burden and risks
There is no risk associated with participation in the study. The burden on the
subject is minimal because all measurements are non-invasive. The measurements
are done using patches placed on the abdomen and chest are attached, a cuff
around the finger and breathe through a mouthpiece. Also, the subject is asked
to breathe in certain breathing patterns (such as 6 and 10 times per minute)
and by using a light resistance to breathing, this can be comfortable. This
does happen for a short time and after that the subject can rest and breathe
regularly.
Meibergdreef 9
1105 AZ Amsterdam
NL
Meibergdreef 9
1105 AZ Amsterdam
NL
Listed location countries
Age
Inclusion criteria
Healty subjeds between 18 and 80 years old.
Exclusion criteria
arrhytmias
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL35515.018.11 |