To investigate the feasibility of imaging and measuring enhancement of colorectal cancers and polyps using iodine mapping after acquiring dual energy abdominal CT scan with intravenous iodine contrast in patients without bowel preparation.
ID
Source
Brief title
Condition
- Malignant and unspecified neoplasms gastrointestinal NEC
- Gastrointestinal neoplasms benign
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Visibility and measurability of colorectal cancer at an iodine map using no
bowel preparation and no colon distension.
Secondary outcome
Visibility and measurability of colorectal polyps at an iodine map using no
bowel preparation and no colon distension.
Technical failures and the reasons for technical failures.
Background summary
Colorectal cancer is the second cause of cancer related death in Europe.
CT-colonography is one of the recommended tools for colorectal screening in
some countries and considered as such in other countries. One of the main
drawbacks of CT-colonography as a screening tool is the bowel preparation that
causes diarrhoea and discomfort. This preparation, with mostly oral iodine
contrast, is needed to create enough contrast of cancer and polyps as compared
to bowel content. Although substantially less burdensome than extensive bowel
preparation, this bowel preparation is still a drawback of CT-colonography.
Recently, dual energy CT has been introduced into clinical practice. Dual
energy CT can distinguish different materials by performing scans at two energy
levels and analyzing the differences in attenuation between these scans. Iodine
has much more attenuation at low energy levels and can therefore be
distinguished well with this technique. An iodine map of the colonic wall can
be constructed after a dual energy CT scan with intravenous contrast is
performed. If *after intravenous contrast medium* colorectal cancer and polyps
are visible at an iodine map, they can be differentiated from stool and this
could obviate the use of any bowel preparation.
Study objective
To investigate the feasibility of imaging and measuring enhancement of
colorectal cancers and polyps using iodine mapping after acquiring dual energy
abdominal CT scan with intravenous iodine contrast in patients without bowel
preparation.
Study design
Prospective observational pilot study
Study burden and risks
The participant will not be exposed to any procedure that would not have been
performed in current clinical practice. A benefit for participants may be a
slightly reduced radiation dose. A single dual energy scan uses a higher
radiation dose as compared with a *normal* single energy scan. Because dual
energy obviates the need for an unenhanced series, the total received radiation
dose may be lower than in current clinical practice. The radiation committee of
the AMC calculated that the effective radiation doses of both protocols are
very similar.
Bronovolaan 5
2597 AX Den haag
NL
Bronovolaan 5
2597 AX Den haag
NL
Listed location countries
Age
Inclusion criteria
> 18 years old
Recent diagnosis of colorectal cancer
Will be sceduled for pre-operative abdominal staging CT
Written informed consent
Known eGFR calculated from maximum 3 months old serum creatinin.
Exclusion criteria
Iodine contrast allergy
Renal function impairment, defined as an eGFR < 40 mL/min
Body mass index > 30 kg/m2
Pregnancy
Design
Recruitment
metc-ldd@lumc.nl
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL34841.098.10 |