1) To determine if microinfarcts can be detected in the brain with 7T MRI in AD patients2) To determine the prevalence and number of cerebral microbleeds on 7T MRI in patients with AD and to relate these lesions to cognition and to the vascular risk…
ID
Source
Brief title
Condition
- Structural brain disorders
- Vascular haemorrhagic disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The prevalence and total number of microinfarcts at 7T
The prevalence and total number of microbleeds at 7T
For the parelsnoer project participants will already receive a full clinical
assessment, neuropsychological tests and a 3T MRI.
Participants in the present study will also undergo some additional
neuropsychological tests and a 7T MRI.
Secondary outcome
• Conventional brain MRI markers of AD (atrophy) and vascular lesions (large
infarcts, white matter hyperintensities) at 3T MRI
• Cognitive profile
• Vascular risk factor profile
Background summary
Microvascular lesions in the brain are a new lead in the etiology of
Alzheimer*s disease (AD). High field strength MRI at 7T should greatly
facilitate the detection of these lesions. We expect that 7T MRI allows us, for
the first time, to detect microinfarcts in living patients. Moreover, we expect
that 7T MRI offers new insights in the relation between microbleeds, cognition
and other relevant clinical variables.
Study objective
1) To determine if microinfarcts can be detected in the brain with 7T MRI in AD
patients
2) To determine the prevalence and number of cerebral microbleeds on 7T MRI in
patients with AD and to relate these lesions to cognition and to the vascular
risk factor profile in these patients.
Study design
This is an observational cross-sectional pilot study at the UMC Utrecht.
Study burden and risks
The physical or psychological risk of the study protocol is minimal. There are
no health risks associated with the procedures and techniques used. The
additional time required for this protocol is limited to 90 minutes.
Lying still in the noisy, small tube of the MRI scanner can be uncomfortable.
Therefore, special attention will be given to inform subjects about the
scanning procedure. A 30 minute scan protocol is part of regular clinical
practice for AD. Our experience is that patients are able to undergo this
procedure without problems. The main difference with daily clinical practice is
the fact that patients receive two scans instead of one.
Heidelberglaan 100, Postbus 85500
3508 GA Utrecht
NL
Heidelberglaan 100, Postbus 85500
3508 GA Utrecht
NL
Listed location countries
Age
Inclusion criteria
Participant of *parelsnoer neurodegeneratieve ziekten* project and diagnosed with (possible) Alzheimer's disease.;For parelsnoer:
referred to memory clinic
subjective and/or objective cognitive impairment
CDR 0, 0.5 or 1
MMSE 20 or higher
Exclusion criteria
Normal pressure Hydrocephalus, M. Huntington
Recent CVA (<2 years), or CVA with subsequent (within 3 months) cognitive deterioration
(History of) Schizophrenia, other psychotic disorders
Major depression
Alcohol abuse
Brain tumour, epilepsia, encephalitis
Absence of reliable informant
Expectation that patient can not be followed for at least 1 year.
Contra-indication for 7 Tesla MR imaging
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL29817.041.09 |