This study should show whether patients with focal BG lesions are impaired in changing the threshold between deliberate fast or accurate conditions, and between conditions with and without prior information. Also, it should show that patients with a…
ID
Source
Brief title
Condition
- Central nervous system vascular disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The LBA model parameter estimates per subject, per condition.
Secondary outcome
Mean reaction time per condition. Mean accuracy per condition.
Background summary
Decision making is highly relevant to everyday life. We can make our decisions
quickly or accurately, but usually not both. When making decisions, we use not
just the information that is in front of us, but also relevant information we
have gathered previously. Previous work using model-based fMRI has implicated
the basal ganglia (BG) in setting the decision threshold for speed accuracy
tradeoff (Forstmann et al., 2008). Other work has shown BG and orbitofrontal
cortex (OFC) activation associated with selective threshold changes in decision
making with prior information (Forstmann et al., in submission). In this study
we examine the involvement of the BG, OFC and IPS (inferior parietal sulcus) in
threshold setting and evidence accumulation. To do so, we will model the
behavior of BG, OFC and IPS lesion patients, in addition to healthy controls.
Study objective
This study should show whether patients with focal BG lesions are impaired in
changing the threshold between deliberate fast or accurate conditions, and
between conditions with and without prior information. Also, it should show
that patients with a focal OFC lesion are impaired in changing threshold in
decision making with prior information, and that patients with IPS lesions show
lower drift rates overall.
Study design
This is an observational study comparing performance in three clinical groups
and a control group. It involves behavioural measures, which will be analyzed
using the Linear Ballistic Accumulator model (LBA; Brown & Heathcote, 2008).
Study burden and risks
This study does not put the patients or control subjects at risk. The
experiment involves a vist to the research centre, which will take
approximately 3.5 hours. This will involve two behavioral tasks, an MRI, and
the filling out of questionnaires.
Kapittelweg 29
6500HB Nijmegen
NL
Kapittelweg 29
6500HB Nijmegen
NL
Listed location countries
Age
Inclusion criteria
group 1. Focal ischemic lesion in the basal ganglia, preferably restricted to the striatum.
group 2. Ischemic lesion in prefrontal cortex, preferably matched in age and lesion size to group 1.
group 3. Ischemic lesion in parietal cortex, preferably matched in age and lesion size to group 1.
group 4. Healthy controls, matched in age and education to group 1.
Exclusion criteria
psychiatric or neurological disorders (aside from inclusion criteria). In particular, other ischemic or haemorrhagic strokes.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL31721.091.10 |