The aim of this study is to test the feasibility, reliability and validity of a Dutch version of the Penn Computerized NeuroPsychological testing system (CNP). It is tested wether our translated version is feasible for use in the Dutch population at…
ID
Source
Brief title
Condition
- Cognitive and attention disorders and disturbances
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Prestatiematen tijdens verschillende CNP taken:
1. Motor Practice Test
2. Emotion Recognition Test
3. Continuous Performance Test (number/letter version)
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4. Face Memory Test
5. Word memory Test (parent/child version)
6. Short Letter N-back test
7. Face Memory Test - Delayed Memory
8. Word memory Test - Delayed Memory (parent/child version)
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9. Conditional Exclusion Test
10. Emotion Differentiation Test
11. Short Computerized Fingertapping Test
12. Matrix Reasoning Test
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13. Visual Object learning Test
14. Logical reasoning (parent/child version)
15. Age Differentiation Test
16. Line Orientation Test
17. Visual Object learning Task - Delayed Memory
Secondary outcome
Covariates: sex and age, body mass index, educational attainment, reading
ability, current profession (for adults), lifestyle information (exercise,
smoking, alcohol), sleep duration, general health, blood pressure, and
medication use.
Background summary
The University of Pennsylvania has developed a computerized neuropsychological
testbattery, which has been used in scientific studies extensively. It was
developed for several reasons, one of which was to overcome logistic problems
that are part of pen-and-paper neuropsychological tests such as long
administration times, and the administration and scoring of these tests that
require training and may vary among administrators. The tests used in the CNP
are based on existing tests, but have been modified to computer administration,
providing domain scores for accuracy, speed and efficiency on all tasks. The
CNP tests performance on a range of cognitive measures, like speed of
information processing, emotion processing, attention, memory and executive
functions. The battery used here consists of 17 subtests and takes on average
one hour to administer. The cognitive functions that these tasks measure have
proven to be related to brain structures and functioning, to be associated with
psychiatric disorders, and to be heritable. Because of this, the tests are
considered good endophenotypes in genetic studies for example for
schizophrenia, and anxiety and depressive disorders.
Study objective
The aim of this study is to test the feasibility, reliability and validity of a
Dutch version of the Penn Computerized NeuroPsychological testing system (CNP).
It is tested wether our translated version is feasible for use in the Dutch
population at large, specifically adolescents and their parents. Relevant
questions are, for example, do subjects understand the instructions at all ages
and education levels. Are there floor or ceiling effects in one or more
subtests? What is the distribution of the performance scores? Can the CNP be
administerde at home with a laptop? What are the physiological reactions of the
study?
In addition, the reliability of performance on the 17 subtests is assessed by
examining the monozygotic twin correlation as a proxy for test-retest
reliability. Validity of the battery will be tested by comparing the mean
scores and distrubutions to those obtained in different countries (for instance
UK and the US), and by testing the effects of educational attainment. The final
goal is the availability of a Dutch translation of the Penn Web-based
Neurocognitive Battery that is used in many countries in reserach on normal and
abnormal brain development.
Study design
During the study the twin families can visit the VU University or will be
visited at home by two researchers/assistants. Using a laptop version of the
Penn Neurocognitive test battery and a short interview data will be collected
on:
1. performance on 17 subtests reflecting 30 different cognitive functions
(information processing speed, emotion recognition, attention, short and long
term memory, executive functioning).
2. covariates including sex and age, body mass index, educational attainment,
reading ability, current profession (for adults), lifestyle
information(exercise, smoking, alcohol), sleep duration, general health, blood
pressure, and medication use.
Administration of the Neurogcognitive test battery will take approximately one
and a half hour. Two subtests, Word Memory test and the Short Logical
reasoning test have special versions for adults and children. In between
testing we take three breaks ; in the last break a short interview is conducted
to assess the covariates. During the other breaks the blood pressure will be
measured.
Study burden and risks
The computer test battery has been constructed to be as user friendly as
possible. Instructions emphasize that some of the trials wiil be very hard on
everybody. We deliberately make it possible that the families can choose
between visiting the VU University or be visited at home to reduce the total
time that they need to invest in the study as much as possible.
van der boechortstraat 1
1081 BT Amsterdam
NL
van der boechortstraat 1
1081 BT Amsterdam
NL
Listed location countries
Age
Inclusion criteria
Twin families with twins in the range 13 year or older. Both twins and at least one parent must be willing to participate.
Exclusion criteria
Known neurologic disorders (epilepsy, psychosis, pareses, paralysis, etc) or the use of neuroleptics, antihistaminergic, or antidepressives, pregnancy, cardiac desease (under treatment of the cardiologist); metal objects in thorax.
Design
Recruitment
Followed up by the following (possibly more current) registration
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Other (possibly less up-to-date) registrations in this register
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In other registers
| Register | ID |
|---|---|
| CCMO | NL34493.029.10 |