To measure the wavelength dependent differences in optical properties between normal and malignant breast tissue over a broad wavelength range (400-1000 nm).
ID
Source
Brief title
Condition
- Miscellaneous and site unspecified neoplasms benign
- Breast therapeutic procedures
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The wavelength dependent difference in absorption coefficient between normal
and malignant breast tissue at different locations in the tumor.
Secondary outcome
N/A
Background summary
Photoacoustic mammography is currently under investigation as an alternative
for X-ray mammography. Optimisation of the photoacoustic mammography image
contrast involves determination of the optimal contrast wavelength.
Study objective
To measure the wavelength dependent differences in optical properties between
normal and malignant breast tissue over a broad wavelength range (400-1000 nm).
Study design
Observational study.
Study burden and risks
The burden and risks associated with participation are minimal; optical
measurements are performed with sterile optical needles with the patient under
general anesthesia, prior to mastectomy. Measurements are only taken in tissue
that will be removed by the surgeon. The total time taken by the measurements
is less than 10 minutes. The patients will not benefit from the study.
Dr. Molewaterplein 50
3000 CA
NL
Dr. Molewaterplein 50
3000 CA
NL
Listed location countries
Age
Inclusion criteria
Patients undergoing modified radical mastectomy, with preferably palpable tumors at large distance from the musculus pectoralis.
Exclusion criteria
- Nipple sparing/skin sparing mastectomy
- Patients with silicone breast implants
- Patients with increased risk based on a poor general condition
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL34707.078.10 |