Determining blood levels of various (micro)nutrients (Fe, Zn, Cu, Mg, vitamins B6 and D3, the essential fatty acids epa, dha and aa) and lead, as well as ferritine, in a group of forensic patients, in order to establish if these values deviate from…
ID
Source
Brief title
Condition
- Other condition
- Impulse control disorders NEC
Synonym
Health condition
agressie, zowel fysiek en verbaal
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Blood levels of:
- lead
- the fatty acids arachidonic acid, eicosapentanoenic acid and
docosahexanoenic acid
- the relation between these levels and reference measures
Behavioural measures:-
- aspects of actual aggression (AVL: self rated aggressive tendencies; SDAS
aggression according to staff).
Secondary outcome
Blood levels of:
- iron
- zinc
- copper
- magnesium
- vitamin B6
- vitamin D3
- ferritine
- the relation between these levels and reference measures
Behavioural measures:-
- psychiatric diagnosis
- general health and wellbeing (GHQ-28), and psychiatric symptoms (SCL-90)
- risk assessment scores(HCR-20 scales)
- aspects of actual aggression (SOAS-R: severity and frequency of aggression
incidents)
Background summary
Research shows an association between micronutrient and heavy metal blood lead
levels, and psychiatric/neurological/neuro cognitive disorders. Similar
associations have been suggested with criminal/antisocial behaviour. Research
on the effects of the above mentioned substances on people suffering
psychiatric illness who also show criminal/antisocial behaviour did not take
place in a systematic way so far.
The proposed research intends to fill this void.
Study objective
Determining blood levels of various (micro)nutrients (Fe, Zn, Cu, Mg, vitamins
B6 and D3, the essential fatty acids epa, dha and aa) and lead, as well as
ferritine, in a group of forensic patients, in order to establish if these
values deviate from reference values or values found in other populations.
Furthermore, the predictive value of the above mentioned blood levels in
relation to severity of psychiatric disorders and antisocial or dangerous
behaviour will be studied
Study design
A preliminary, descriptive, study. Blood levels as well as relations between
variables will be under investigation. Furthermore (multiple) regression
techniques will be used to find out if the determined blood levels have
predictive value concerning behaviour (incidents in particular)
Study burden and risks
A once-only blood sample will be asked. At the time of blood sampling a number
of questionnaires will be administered. The procedure takes about 30 minutes.
The risk of this procedure is limited to the (minimal) risk of venous blood
sampling
Dolderseweg 164
3734 BN Den Dolder
NL
Dolderseweg 164
3734 BN Den Dolder
NL
Listed location countries
Age
Inclusion criteria
- having committed an impulsive and/or aggressive crime
- currently hospitalised on a forensic psychiatric ward
- any DSM-IV axis I and/or II diagnosis
- age >18 year
Exclusion criteria
- the inability to give informed consent
- Primary neurological disorder (ICD-10: F00.xx -F09.xx).
- any reason - according to the judgement of the psychiatrist - contraindicating participation
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
Register | ID |
---|---|
CCMO | NL26340.041.10 |