To assess the involvement of a specific genetic risk allele on oxidative stress induced by neutrophils in relation to H. pylori infection.
ID
Source
Brief title
Condition
- Gastrointestinal infections
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The production of ROS by neutrophils related to the NCF4 mutation and H. pylori
status.
Secondary outcome
In H. pylori positive patients: CagA, VacA and OipA status. Pepsinogen I, II
and gastrin 17 level.
Background summary
Infection with H. pylori is still prevalent, especially in developing countries
and ethnic minorities in Western urban areas. It can be the starting point for
the development of serious diseases like duodenal ulcer and gastric
adenocarcinoma. Until now, it is difficult to select patients with the highest
risk for getting these diseases. We hypothesize that in people bearing a
specific risk allele the production of ROS by neutrophils is impaired in
response to H. pylori infection.
Study objective
To assess the involvement of a specific genetic risk allele on oxidative stress
induced by neutrophils in relation to H. pylori infection.
Study design
Mono-center, laboratory study. Patients who are referred for a diagnostic urea
breath test (UBT) to identify active H. pylori infection will be asked for
consent for taking blood. Blood samples will be used to assess immune cell
activity in relation to H. pylori and a host genetic risk factor.
Study burden and risks
After informed consent blood samples will be taken by vena puncture, the only
extra procedure. Four tubes will be obtained once. Except a superficial
hematoma, no risks are to be expected.
's Gravendijkwal 230
Rotterdam 3015 CE
NL
's Gravendijkwal 230
Rotterdam 3015 CE
NL
Listed location countries
Age
Inclusion criteria
- Patients referred for Urea Breath Test (UBT)
- Age > 18 years
- Informed consent
Exclusion criteria
None
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL40866.078.12 |