To test the suitability of the PortaLite fNIRS device for measuring brain activity during dual tasking performed by elderly with Parkinson*s Disease (PD) and design a valid and feasible protocol for this measuring.
ID
Source
Brief title
Condition
- Movement disorders (incl parkinsonism)
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The signal-to-noise ratio of the PortaLite.
Secondary outcome
Changes in OxyHb, DeoxyHb, and total Hb in µmol/L from baseline to mean maximum
value of a certain task measured with fNIRS
Subjective perceived exertion is measure with a questionnaire (Borg schaal RPE)
Background summary
Dual tasking, the performance of two tasks simultaneously, is very common in
daily life. It may lead to interference and decline in performance of one or
both tasks. Parkinson*s disease (PD) is related to an increased decline in
performance of dual tasks. Measuring brain activity is the most appropriate way
to investigate what happens in the brain during dual tasking and to investigate
the problems of decline in performance. Functional Near-Infrared Spectroscopy
(fNIRS) is a technique in which cerebral cortex activation is measured
indirectly due to event-related haemodynamic changes.
Study objective
To test the suitability of the PortaLite fNIRS device for measuring brain
activity during dual tasking performed by elderly with Parkinson*s Disease (PD)
and design a valid and feasible protocol for this measuring.
Study design
Cohort study
Study burden and risks
The burden of participating in the study is relatively small and we expect no
risks for the subjects. There is no benefit for the subjects of participating
in the study. The aim of this study is to test the feasibility and validity of
the protocol in the group of PD patients in which the device and protocol will
be actually used.
Reinier Postlaan 4
6525 CG Nijmegen
NL
Reinier Postlaan 4
6525 CG Nijmegen
NL
Listed location countries
Age
Inclusion criteria
Age 60-85 years
Diagnosis Parkinson*s Disease UKBB
Hoehn and Yahr stage II-III (on medication)
2 or more falls within the 6 months prior to the study
Able to walk at least 5 minutes unassisted (walking aid allowed)
Deep Brain Stimulation parameters and medication stable for at least one month
Exclusion criteria
Psychiatric co-morbidities (e.g., major depression - DSM IV criteria)
History of stroke, traumatic brain injury, brain tumor or other neurological disorders
Acute lower back or lower extremity pain, musculoskeletal injuries, peripheral neuropathy which restricts gait
Clinical diagnosis of dementia (e.g., Alzheimer*s disease, vascular dementia)
Severe freezing precluding safe participation
Unable to comply with testing protocol
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL40985.091.12 |