The aim is to optimize the brain imaging technique; specifically the settings for the ASL MRI sequence, and to explore the parameters of use to our study.
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
er wordt niet gekeken naar een aandoening, maar naar de toepassing van de techniek
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
CBF measured with ASL (ml/100 gr/min), and cerebral auto regulation measured
with TCD (cm/s), NIRS (concentration oxy/deoxy Hb in mmol/L)
Secondary outcome
non
Background summary
ASL is a technique with which one can measure cerebral perfusion in a MRI
scanner. This MRI technique will be used in an intervention study later this
year. Prior to testing AD patients for the intervention study, 10 healthy
elderly will be measured using ASL MRI to optimize the brain imaging technique.
The quality of these images will be compared, and subsequently the most optimal
scan settings will be used for the ASL measurements in the NILVAD study.
Furthermore, the ASL MRI measurements will be compared with TCD and NIRS data.
Study objective
The aim is to optimize the brain imaging technique; specifically the settings
for the ASL MRI sequence, and to explore the parameters of use to our study.
Study design
Elderly who fulfill the criteria are informed about the study. When willing to
participate, they are asked for their written informed consent. The study is
comprised of one visit to the hospital. Participants will be asked to first
undergo MRI (taking approximately one hour), followed by a combined TCD/ NIRS
measurement (taking approximately two hours). Based on the data from the first
six participants, we will determine if any more measurements (i.e.
participants) are necessary, up to a maximum of ten participants.
Study burden and risks
Participation will cost only one visit of approximately three hours and travel
expenses will be reimbursed. The techniques used (MRI, TCD/NIRS) have no risk
for the participants. Healthy elderly are preferred, as they are as close in
comparison with Alzheimer*s patients, and to keep the burden for patients to a
minimum.
Reinier Postlaan 6
NIJMEGEN 6525 GC
NL
Reinier Postlaan 6
NIJMEGEN 6525 GC
NL
Listed location countries
Age
Inclusion criteria
healthy elderly aged over 50 years, MMSE score over 25
Exclusion criteria
neurological or psychiatric disorders
contraindication for MRI (metal implantates, claustrophobia)
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL41054.091.12 |