The objective of the study is to examine the relation between changes in cortical activity during movement observation and execution, and changes in motor function and motor control after stroke. The hypotheses to study this objective are: 1. Brain…
ID
Source
Brief title
Condition
- Vascular haemorrhagic disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The correlation between changes in motor control and motor function and
cortical activity is measured by comparing the scores of the grip strength
(motor control) and the Fugl-Meyer motor assessment (motor function) with the
changes in activity of the cortex. The activity of the brain is summarized in
*topoplots* showing the degree of (de)synchronization by a colorscale projected
on a headmodel. Change of activity of the cortex is quantified by calculating
the event related synchronization (i.e. the difference in power of the EEG
between the resting and the action condition), and the Brain Symmetry Index
(i.e. the symmetry of the activity between the two hemispheres).
Secondary outcome
There are no secundary study parameters
Background summary
After stroke, many people suffer from motor function impairment. During the
period of rehabilitation, changes occur in the activation of the brain. These
changes are thought to relate to motor function recovery after stroke.
During the execution of a movement, the motor areas of the brain are active.
Previous studies found that also during observation of a movement these motor
areas are activated. In order to understand the relation between cortical
activity during observation and execution of movements and motor fucntion
recovery after stroke, the current study will examine the changes of cortical
activity during the first few months after stroke during movement observation
and movement execution. These changes will be related to motor function and
motor control.
Study objective
The objective of the study is to examine the relation between changes in
cortical activity during movement observation and execution, and changes in
motor function and motor control after stroke. The hypotheses to study this
objective are: 1. Brain activity during movement observation after stroke
correlates with the brain activity during the execution of a movement; 2.
Changes in motor function correlate with changes in cortical activity during
observation of a movement; 3. Movement observation in addition to movement
execution results in an increased cortical activity compared to movement
without observation.
Study design
The study is a longitudinal study, with 4 measurements divided over 4 months.
Study burden and risks
Four measurements will be done, 1 in the Medisch Spectrum Twente, while the
patient is admitted to the hospital.
For the three following measurements, the patient will be asked to return to
the hospital. Each measurement will be the same and takes about 2 hours. Each
measurement is started with the assessment of the grip strength, followed by
assessment of motor function by using the *upper-extremity part* of the
Fugl-Meyer motor assessment.
EEG is measured during rest with eyes openend (1 minute), and eyes closed (1
minute), and while the patient watches a movie of about 9 minutes showing a
moving hand or a moving dot (rest condition). In addition, the patient sees the
movie while executing the movement his-/herself. Thereafter, the patient has to
make the movement by his-/herself without the movie (20x 5 seconds, with each
hand). The movement to be made is a tweezers grip (the top of the thumb to the
top of the indexfinger). If the patient is not able to execute the movement,
the patient only has to try 20 times, 5 seconds.
No risks are involved in the study.
P.O. Box 50 000
7500 KA Enschede
NL
P.O. Box 50 000
7500 KA Enschede
NL
Listed location countries
Age
Inclusion criteria
- First ever ischemic stroke
- Unilateral cortical and/or subcortical stroke
- Stroke < 1 week ago
- Some motor dysfunction of the arm/hand (MRC < 5)
- Age between 18 and 80 years
Exclusion criteria
- Other (pre-existing) neurological diseases (e.g. epilepsy, tumor, paralysis)
- Autism spectrum disorders, PDD, schizophrenia (or history of schizophrenia)
- Instable medical health situation (cardiovascular and/or neurological)
- Uncompensated hemineglect or cognitive disabilities, resulting in misunderstanding or incapability of executing instructions given
- Uncorrected visual problems, i.e. not able to observe the movie on the screen
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL22476.044.08 |