Objective 1: to examine the relation in wall thickness and diameter across arteries that are prone (i.e. carotid, femoral, superficial femoral and popliteal) and resistant (i.e. brachial and radial) against atherosclerosis in healthy volunteers and…
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
hypertensie
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
1) Wall thickness
2) Flow-mediated dilation
Secondary outcome
not applicable
Background summary
Atherosclerosis is an important proces that contributes to the development of
cardiovascular disease. Atherosclerosis is characterised by thickening of ther
arterial wall. Several studies found that the carotid artery wall thickness is
a good measure for the process of atherosclerosis and has a strong predictive
capcity for future cardiovascular events. These studies primarily focused on
the carotid artery, but relatively little is known about the process of wall
thickening in other arteries in the upper and lower limbs. In addition, little
is known whether the impact of hypertension on carotid artery wall thickening
is similar to that observed in arteries of the lower and upper limbs.
In the 1950s, Prof. Folkow provided evidence that a thicker wall is related to
a larger responsiveness of the same artery. Recently, we could confirm this
hypothesis for conduit arteies in healthy young men as a larger dilator
responsiveness was observed in arteries with thicker walls. Whether a similar
relation is also present in subjects with cardiovascular risk factors (which
typically lead to thickening of the arterial wall) is currently unknown.
Study objective
Objective 1: to examine the relation in wall thickness and diameter across
arteries that are prone (i.e. carotid, femoral, superficial femoral and
popliteal) and resistant (i.e. brachial and radial) against atherosclerosis in
healthy volunteers and those with hypertension.
Objective 2: to examine the relation between wall thickness and dilator
function in healthy volunteers and those with hypertension.
Study design
observational, cross-sectional pilot study
Intervention
n/a
Study burden and risks
Subjects will visits our laboratory twice; once for a screening (0.5 h) and
once for the test (2 h). During the test, we will measure diameter and wall
thickness of the carotid, brachial, radial, femoral, superficial femoral and
popliteal artery. In addition, we will examine the endothelium-dependent and
independent dilation of the brachial and superficial femoral artery. This will
be performed with non-invasive tests with a minimal burden for the subjects.
Geert Grooteplein-noord 21
6525 EZ Nijmegen
NL
Geert Grooteplein-noord 21
6525 EZ Nijmegen
NL
Listed location countries
Age
Inclusion criteria
Subjects with hypertension (diastolic >90 and/or systolic >140 and/or use of medication against hypertension) and their age- and sex-matched controls.;Subjects with hypertension have a blood pressure (after 5 min seated rest, measured twice) of >=140 systolic or >=90 diastolic blood pressure or the use of prescribed anti-hypertension medication.
Exclusion criteria
For all subjects
- Diagnosis of cardiovascular disease
- Diabetes Mellitus type I or II
- smoking
- women on hormone replacement therapy
- Family history of acute cardiac death (< 50 years of brother/sister or father/mother).
- Hypercholesterolemia (>=6.5 mmol/L or use of statins).
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL38908.091.11 |