The current proposal studies the effect of obesity and asthma on daily physical activity level in children.
ID
Source
Brief title
Condition
- Other condition
- Congenital respiratory tract disorders
Synonym
Health condition
Overgewicht en obesitas
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The main study parameter is the step count per day. Secondary parameters are:
FEV1, FVC, %reversibility, FeNO, several EBC-markers, amount of screen time/wk,
amount of time spent in intense physical activity/wk and amount of time spent
in active transportation/wk.
Secondary outcome
NVT
Background summary
Overweight and obesity has reached epidemic proportions worldwide. In Southern
Limburg, overweight is present in 18% of the boys and 15,5% of the girls. A
meta-analysis demonstrated an increased risk on the development of asthma in
overweight children (1). At least three possible hypotheses are plausible (2,
3): 1) an effect of obesity on pulmonary physiology and lung function; 2) an
effect of obesity on airway inflammation; 3) an increase in gastro-oesophageal
reflux. However, none of these hypotheses have been adequate. The increase in
asthma, obesity and a sedentary lifestyle have occurred together (4). As
obesity is characterized by a sedentary lifestyle, the question rises whether
children with asthma are also less physically active. The current literature is
unable to answer this question. Therefore, it is unknown what role physical
activity plays in the asthma-obesity relation. To investigate this, studies
should first investigate whether the daily physical activity level differs
between children with asthma (A), asthma and obesity (AO), obesity (O) and
children without asthma and obesity (healthy controls). We expect that the
physical activity levels of children with respectively A and O are lower in
comparison to healthy controls. Furthermore, we hypothesize that the activity
level of children with AO will be even lower.
Study objective
The current proposal studies the effect of obesity and asthma on daily physical
activity level in children.
Study design
During one visit, children will perform a lung function test (Flow-volume
curve), a Fractional exhaled Nitric Oxide (FeNO) measurement, and Exhaled
Breath Condensate (EBC) will be collected. Moreover, body weight and length of
the child will be measured. The children will wear a pedometer in their pocket
for 7 consecutive days. At the end of each day they will fill in their
swimming- and cycling time. Parents will fill in a general questionnaire about
their child*s physical activity level and respiratory symptoms.
Study burden and risks
The visit will take approximately 45 minutes. Only non-invasive measurements
and questionnaires will be assessed. There are no associated risks or benefits
for the participants in this study.
P. Debyeplein 28
6202 AZ
NL
P. Debyeplein 28
6202 AZ
NL
Listed location countries
Age
Inclusion criteria
- Children aged 6-12 years
- Residential in Southern Limburg
Asthma obesity group:
- A BMI in the overweight/obesity range according to LMS method of Cole et al and reference values of the fourth national Growth study. A BMI-SDS of >1.1 is considered as overweight.
- An asthma diagnosis of the GP or pediatrician (>=9%FEV1 reversibility after 400 µg salbutamol) and/or medication suggestive for asthma (at least one daily dosis equivalent of Short acting Beta-2agonists, Long acting Beta-2agonists or inhaled corticosteroïds).
Obesity group
- A BMI in the overweight/obesity range according to data of the fourth national growth study (BMI-SDS>1.1)
- No asthma diagnosis of the GP or pediatrician and no symptoms and medication suggestive for asthma.
Asthma group
- An asthma diagnosis of the GP or pediatrician, with symptoms (>=9%FEV1 reversibility after 400 µg salbutamol) and/or medication suggestive for asthma (at least one daily dosis equivalent of Short acting Beta-2agonists, Long acting Beta-2agonists or inhaled corticosteroïds).
- A BMI in the normal weight range according to data of Cole et al [31].
Healthy controls:
- A BMI in the normal weight range according to data of the fourth national growth study (BMI-SDS in between -1.8 and 1.1)
- No asthma diagnosis of the GP or pediatrician and no symptoms and medication suggestive for asthma.
Exclusion criteria
- Children with Congenital malformations of the airways or other chronic lung diseases like cystic fibrosis (CF)
- Children with Mental retardation or syndromes
- Children with heart diseases
- Children with physical limitations which make intense physical activity impossible
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL40345.068.12 |