Our goals are to collect blood from men randomized to the intervention arm of the Dutch part of the European Randomised study of Screening for Prostate Cancer (ERSPC) and actually screened (www.erspc.org, N=19.970, METC 138.741/1994/152). With the…
ID
Source
Brief title
Condition
- Reproductive neoplasms male malignant and unspecified
- Prostatic disorders (excl infections and inflammations)
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
SNPs profiling of 110 known SNPs and relate those to the available follow-up
data containing information of prostate cancer detection, treatment,
progression and casus specific death.
Secondary outcome
Assess the possibilities to enhance existing risk stratification tools with
genomic based information.
Background summary
Screening for prostate cancer (PC) can reduce the suffering from metastatic
disease and disease specific mortality. The applied Prostate Specific Antigen
(PSA) based screening algorithm has however major drawbacks, resulting in a
heavily debated healthcare conundrum. Recent advances in genomic research have
made it possible to identify genomic based biomarkers for PC. These markers are
easy to measure and stable over time. The current challenge now is not only to
identify biomarkers but to validate these in wellcharacterized study cohorts.
Study objective
Our goals are to collect blood from men randomized to the intervention arm of
the Dutch part of the European Randomised study of Screening for Prostate
Cancer (ERSPC) and actually screened (www.erspc.org, N=19.970, METC
138.741/1994/152). With the isolated DNA we will perform profiling of
established diagnostic and prognostic PC single nucleotide polymorphisms
(SNPs).
Study design
This is an observational study.
Study burden and risks
Participants in this study have no benefit form participation in the trial.
This is acceptable as the only study procedure is one blood withdrawal which is
associated with very low risks.
's-Gravendijkwal 230
Rotterdam 3015 CE
NL
's-Gravendijkwal 230
Rotterdam 3015 CE
NL
Listed location countries
Age
Inclusion criteria
- Men randomised to the screening arm of ERSPC Rotterdam
- Signed informed consent
Exclusion criteria
None
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL39913.078.12 |