The aim of this study is to investigate the interobserver variation in assessment of acute posthypoxische myoclonus in patients after cardiopulmonary resuscitation.
ID
Source
Brief title
Condition
- Seizures (incl subtypes)
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Intraclass correlation coefficient in assessing acute posthypoxic myoclonus in
patients after cardiopulmonary resuscitation.
Secondary outcome
Investigate characteristics of clinical neurophysiological investigations
(electroencephalography (EEG) and somatosensory evoked potentials (SEP)) in
patients with acute posthypoxic myoclonus after cardiopulmonary resuscitation.
Background summary
Acute posthypoxic myoclonus consists of a spectrum that ranges from focal
myoclonus to status myoclonus. It occurs in 19-37 % of the patients admitted to
the intensive care unit after cardiopulmonary resuscitation. The diagnosis of
acute posthypoxic myoclonus is based on clinical observation and can largely
contribute to treatment decisions. However, interobserver agreement of this
clinical observation is unknown.
Study objective
The aim of this study is to investigate the interobserver variation in
assessment of acute posthypoxische myoclonus in patients after cardiopulmonary
resuscitation.
Study design
An international multicenter prospective cohort study will be performed at the
intensive care unit.
Study burden and risks
Video registrations of the patient will be performed once or twice, depending
on the administration of drugs. Standard clinical neurologic examination is
part of the video protocol. Each video-registration will last 15-30 minutes.
Thirty days after cardiopulmonary resuscitation a telephone interview (5-10
minutes) with the patient or his/her legal representative will be performed to
evaluate the neurological outcome according to the Cerebral Performance
Category-score. The neurological examination performed during the video
registration is part of every day clinical practice. Therefore, the risk
associated with participation can be considered negligible and the burden is
minimal.
Meibergdreef 9
Amsterdam 1105 AZ
NL
Meibergdreef 9
Amsterdam 1105 AZ
NL
Listed location countries
Age
Inclusion criteria
Admission after CPR (cardiac or hypoxic arrest)
Acute posthypoxic myoclonus within 72 hours after admission
Exclusion criteria
Age < 18 years
Presence of myoclonus before CPR
Traumatic cause of CPR (hypovolemic arrest)
Severe traumatic brain injury
Medical history of epilepsy / Epilepsy syndromes in which myoclonus is prominent and in which patients can develop myoclonus status epilepticus such as juvenile myoclonic epilepsy and progressive myoclonic epilepsies
Possible explanations for seizures or myoclonus other than the anoxic-ischemic event
Generalized tonic-clonic seizure(s) as cause of the myoclonus
Drug overdose
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL38396.018.11 |