The aim of this study is to compare the integrity of the corticospinal tract and cortical reorganization of shoulder girdle muscle representations in chronic stroke patients with and without GHS as well as healthy controls.
ID
Source
Brief title
Condition
- Central nervous system vascular disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Main study parameters are TMS induced motor evoked potentials (MEPs) and the
extent of the motor surface map.
Secondary outcome
not applicable
Background summary
In 2004, 216.500 inhabitants of the Netherlands had to live with the
consequences of stroke. The increase of life expectancy and the development of
medical science will result in a higher prevalence of stroke survivors. The
consequences of stroke (impairments and disabilities) have a major impact on,
among other things, the activities of daily living. Glenohumeral subluxation is
one of the consequences of stroke. Subluxation makes the shoulder vulnerable to
injuries, causes a reduced use of the arm, hinders the rehabiliation process
and may become painful, thus creating a vicious circle. Current mechanisms that
explain glenohumeral subluxation use a musculoskeletal perspective. However,
these mechanisms are under strong debate. Until now, persistent glenohumeral
subluxtion has never been studied or explained by the role of coritcal changes
that occur after stroke. Transcranial magnetic stimulation (TMS) is a
non-invasive method that applies magnetic pulses over the skull, causing
depolarisation of nerve fibers in the cortex. When this stimulation is done
over the motor cortex, the role of this cortex can be assessed with regard to
persistent glenohumeral subluxation.
Study objective
The aim of this study is to compare the integrity of the corticospinal tract
and cortical reorganization of shoulder girdle muscle representations in
chronic stroke patients with and without GHS as well as healthy controls.
Study design
This is a cross-sectional study
Study burden and risks
The estimated invested time per person is 1 hour and a half. To ensure that
subjects with increased risk for TMS application are excluded for the study, a
TMS questionnaire will be used. Persons will only be admitted to the study
after medical approval by dr Pijlman. Risks of unfavourable effects induced by
TMS in this study is not to be expected for healthy subjects or stroke
patients. Although some participants report transient headache.
Universiteitssingel 50
6229 ER
NL
Universiteitssingel 50
6229 ER
NL
Listed location countries
Age
Inclusion criteria
Subjects will be chronic stroke patients (time post stroke between 6 months and 10 years), with (n<=12) and without (n<=12) glenohumeral subluxation. All patients are able to give their informed consent. The age-matched control group exists of healthy subjects without stroke (n<=12). All subjects are between 45 and 75 years old.
Exclusion criteria
The exclusion criteria for the stroke paitents are:
- Pre-stroke shoulder damage or disorder that may interfere with glenohumeral subluxation or the ability to activate shoulder girdle muscles.
- A history of epilepsy, severe aphasia, implanted electrical devices, metal implants in close proximity to the TMS coil.
- Pregnancy, brain tumour, brain infection, medication that potentially lowers seizure treshold.
The exclusion criteria for the healthy controls are:
- Any acquired brain injury
- Shoulder damage or disorder.
- A history of epilepsy, severe aphasia, implanted electrical devices, metal implants in close proximity to the TMS coil.
- Pregnancy, brain tumour, brain infection, medication that potentially lowers seizure treshold.
Design
Recruitment
Medical products/devices used
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL38578.068.11 |