To examine how sensitive certain (combinations of) EEG parameters are for diagnosing delirium in a heterogeneous group of ICU patients during 24 hours of EEG registration. The delirium assessment by delirium experts will determine which patients…
ID
Source
Brief title
Condition
- Deliria (incl confusion)
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Quantitative EEG characteristics, clinical diagnosis of delirium three times a
day by a group of two delirium expert based on DSM-IV criteria
Secondary outcome
-Classification of delirium based on CAM-ICU and ICDSC screening by ICU nurses
-Determination of electrodes that can be used for calculation of EEG
characteristics and electrodes vulnerable for noise and movements artefacts.
Background summary
Delirium is a common disorder in the intensive care unit (ICU), but poorly
recognized by ICU physicians and -nurses. Electroencephalography (EEG) appeared
to be a sensitive tool for the diagnosis of delirium, but this knowledge was
never implemented in a continuous monitoring system. However, to provide
continuous delirium detection in ICU, the EEG characteristics should be
compared at several moments during recording with the diagnosis of delirium
experts (gold standard) in a heterogeneous group of ICU patients. Thereby, the
most sensitive EEG parameters for the detection of delirium can be determined
and at the same time it can be determined how sensitive these EEG parameters
are when compared to the gold standard.
Study objective
To examine how sensitive certain (combinations of) EEG parameters are for
diagnosing delirium in a heterogeneous group of ICU patients during 24 hours of
EEG registration. The delirium assessment by delirium experts will determine
which patients suffer from delirium and this will be used to determine the
sensitivity of certain EEG parameters for detecting delirium.
Study design
Observational study
Study burden and risks
The burden is a 24 hour EEG recording with a limited number of electrodes. This
burden is minimal and this type of EEG recording is therefore more and more
standard practice in several ICUs. EEG recording has no risks. The burden
further includes three evaluations by a group of 2 delirium experts. There is a
group-related benefit, as development of an objective tool for delirium
detection may improve treatment and therefore outcome.
Heidelberglaan 100
Utrecht 3584 CX
NL
Heidelberglaan 100
Utrecht 3584 CX
NL
Listed location countries
Age
Inclusion criteria
-Informed consent
-Age of 18 years or older
Exclusion criteria
-Comatose patients defined as Richmond Agitation-Sedation Scale (Rass) score < -2 or a Glasgow Coma Scale < 8.
-No communication possible with patient or legal representative due to language barrier or deafness
-Admission for a neurological or neurosurgical disorder
-Expected discharge from the ICU or death within 24 hours
-Patients who participated in this study earlier
-Use of continuous veno-venous hemofiltration or extracorporeal membrane oxygenation, as these therapies result in a specific noise on the EEG.
-Patients in which EEG due to practical reasons not possible is.
-Patients who receive isolation precautions due to infection.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL39653.041.12 |