The objective of the study is to investigate the effect of chewing gum with and without magnolia extract on the composition of dental plaque and saliva. In addition the influence of chewing gum on the wettability of the tooth surface will be studied…
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
het betreft geen directe aandoening er wordt naar tandplaque gekeken.
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The primary study parameter is the percenatge live and dead bacteria isolated
form chewing gum with and without magnolia extract and the composition of the
oral microflora in dental plaque and saliva.
Secondary outcome
the secundairy outcome is the wettability of the toothsurface after use of
various chewing gums and the cleaniness feeling of the toothsurface.
Background summary
It is generally accepted that dental plaque is related to caries and
periodontitis. The cariogenicity of dental plaque is dependent on the bacterial
species in the plaque, the food which is taken and the saliva flow. Adhesion of
these cariogenic bacteria to the tooth surface is very important for the
cariogenic effect. There is a relation between the consumption of carbohydrate
rich food and caries, but also the frequency of taking food plays an important
role. Saliva has a protecting role for the tooth surface against the produced
acids and depends on the amount of saliva and the quality. Saliva removes the
acids and the buffer capacity takes care that the pH goes back to neutral.
Chewing gum has a stimulating effect on the saliva flow. These days a lot of
components as antimicrobial plant extracts are added to chewing gum and have an
anticariogenic action.
Magnolia Berk extract inhibits the growth of Streptococcus mutans,
Streptococcus sobrinus, Porphyromonas gingivalis, Fusobacterium nucleatum.
Another very important characteristic of antimicrobials is that they can adhere
to soft and hard tissues and dental plaque in the oral cavity for sometime.
Subsequently they start releasing to saliva and dental plaque and therewith
extend there action for a longer time, which is called substantivity.
Toothpaste and mouthrinses are the vehicles for antimicrobials distribution in
the oral cavity. Since tooth brushing is a difficult task for a lot of people
for which the importance is under estimated we believe it is a good idea to
search for an alternative vehicle to distribute antimicrobials to the oral
cavity as e.g. chewing gum.
Study objective
The objective of the study is to investigate the effect of chewing gum with and
without magnolia extract on the composition of dental plaque and saliva. In
addition the influence of chewing gum on the wettability of the tooth surface
will be studied.
Study design
It is a double blind study, the researchers and volunteers do not know the type
of chewing gum.
Study burden and risks
The burden for the volunteers is that they cannot brush their teeth early in
the morning on the survey day, during the study period they need to chew three
times a day two pieces of chewing gum for 10 min. There are no predictable
risks in this study.
Antonius Deusinglaan 1
9713 AV
NL
Antonius Deusinglaan 1
9713 AV
NL
Listed location countries
Age
Inclusion criteria
-at least 16 original teeth need to be still available
-volunteers need to be healthy
Exclusion criteria
- if they have used antibiotics in the three months before the investigation started
- if they have been used a mouthrinse in the month before the investigation started or during the study
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL38434.042.11 |