The main objective is to study the intra-individual fluctuations in the physiological responsiveness of the HPA-axis and the ANS in healthy participants, and to test the influence of stressful events, sleep and activity on these fluctuations. The…
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
Het betreft een beschrijving van de normale fysiologie. Uiteindelijk is deze kennis nuttig voor meerdere aandoeningen, aangezien stress hormonen worden beschouwd als generieke risicofactoren voor ongezondheid, waaronder medisch onverklaarde klachten.
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
levels of cortisol, catecholamines, and alfa-amylase in saliva, urine, hair,
and nails
Secondary outcome
common somatic and psychiatric complaints
Background summary
Stress has been linked to medically unexplained symptoms and syndromes. It is
often thought that these associations occur due to activations of the major
stress-axes in the body: the hypothalamic pituitary adrenal-axis (HPA-axis) and
the autonomic nervous system (ANS). Previous studies that typically used a
single measurement of the activity of these systems, found small associations
between stress axes activity and health. One important reason for these small
associations is that stress axes fluctuations are only relevant in specific
subgroups of patients, but it is currently impossible to identify these
patients. An alternative design to study the role of the HPA-axis and the ANS
in chronic fluctuating diseases is to use multiple repeated measurements within
individual patients to study the associations between activity of the stress
axes and symptom level. Such an analysis could be able to identify those
patients in which symptoms occur following changes in HPA-axis and ANS
activity. In order to develop a suitable assessment protocol for use in
patients, we first need information on fluctuations in HPA-axis and ANS
activity in healthy participants.
Study objective
The main objective is to study the intra-individual fluctuations in the
physiological responsiveness of the HPA-axis and the ANS in healthy
participants, and to test the influence of stressful events, sleep and activity
on these fluctuations. The secondary objective is to study the associations
between cortisol and catecholamine levels and common psychiatric and somatic
symptoms within healthy individuals.
Study design
Observational study
Study burden and risks
Participants have to complete a diary for 9 weeks, assessing stressful events,
sleep, activity, and symptom level. At the first day of this period, they also
complete questionnaires on neuroticism, alexithymia and history of life events.
On the first and the last day, they will be asked to provide a small sample of
hair. In addition, they have to collect 24 hour urine, multiple saliva samples,
and blood pressure and heart rate measures in this period. There are no risks
associated with this procedure, and also no benefits.
Postbus 30.001
9700 RB Groningen
NL
Postbus 30.001
9700 RB Groningen
NL
Listed location countries
Age
Inclusion criteria
Healthy Participants, aged 18-65 years.
Exclusion criteria
Use of medication, other than contraceptives or incidental paracetamol
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL39630.042.12 |