At the moment there is level III evidence for the efficacy of the MIT, mainly for the chronic phase. This study intends to establish a higher level of evidence, both for the chronic phase and for the post-acute phase, when aphasia treatment is…
ID
Source
Brief title
Condition
- Other condition
- Central nervous system vascular disorders
Synonym
Health condition
CVA
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
CIU's per minute after 6 weeks of MIT therapy/after 6 weeks of control condition
The amount of information conveyed verbally, measured as the amount of correct
information units (CIUs) on the Sabadel task (telling a story on the basis of
pictures). CIUs are adequate, comprehensible, relevant and informative words in
relation to the picture and are often used as an instrument to measure the
communicative effectiveness of aphasic speech.
Secondary outcome
Repetition task, Spontaneous Speech interview, Amsterdam-Nijmegen Everyday
Language Test (ANELT)
Background summary
Aphasic patients with limited verbal output often show a beneficial effect of
singing on language production. The Melodic Intonation Therapy (MIT) was
devised to use this capacity in the treatment of aphasia, aiming at improvement
of verbal production. The MIT uses the "melodic" elements of language, such as
rythm and intonation. Many case studies have reported spectacular results after
MIT therapy. So far, no systematic effectstudies have been conducted.
THe MIT was based on the RH hypothesis of language recovery, i.e. that RH has
the capacity to take over the language functions of the damaged regions in the
LH.
Recent neuroimaging studies report both left-hemispheric perilesional
activation and RH activiation. However, some studies report that RH activation
may be be related to poor recovery. Possibly, time post onset plays an
importatn role. Some studies suggest that early post-stroke recovery is related
to increased RH activity, whereas late recovery is related with a decrease of
RH activity. Thus, persisting RH activation may be related with poor recovery.
Study objective
At the moment there is level III evidence for the efficacy of the MIT, mainly
for the chronic phase. This study intends to establish a higher level of
evidence, both for the chronic phase and for the post-acute phase, when aphasia
treatment is regularly provided.
Furthermore, it will be investigated whether the efficacy of MIT depends on
patient characteristics such as age, gender, location and seize of lesion and
severity of the aphasia.
fMRI will be used to investigate which brain structures play a role in
MIT-induced recovery. The role of the RH in relation to MIT succes is of
particular interest.
Study design
effect study: randomised waiting-list control study
fMRI study: observational pre-post intervention study. no randomisation
Intervention
Intensive aphasia treatment, namely Melodic Intonation Therapy, during 6 weeks.
Study burden and risks
The experimental treatment, MIT, is given by the participants' regular speech
and language therapist. There are 5 (Group 1) or 6 (Group 2) test sessions of
60 minutes each. These test sessions bring no extra risks. Standard aphasia
tests are administered by the researchers, who vist the participants in the
centre where they reside or receive treatment. Thus, participants do not have
to travel for this study.
Westersingel 300
3015 LJ Rotterdam
NL
Westersingel 300
3015 LJ Rotterdam
NL
Listed location countries
Age
Inclusion criteria
- aphasia after LH stroke
- eligible for MIT
- native speaker of Dutch
- right handed
- age 18-80 yrs
- time post onset: 3-6 maanden
Exclusion criteria
- severe hearing deficit
- dementia
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL19548.078.09 |