To get insight in the effect of S. persica roots on the viability and bacterial composition of dental plaque and saliva
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
microflora van speeksel en tandplaque
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The primary study parameter is the percenatge live and dead bacteria in plaque
and saliva and the similarity (%) between the composition of the oral
microflora of the plaque samples before and after the use of S. persica root.
Secondary outcome
Not applicable
Background summary
Over the years, many antimicrobial substances for oral hygiene have appeared on
the market. Aside from mouthrinses with antimicrobial claims, toothpastes have
also added active ingredients helping with plaque control and holding
antibacterial claims. Besides chemical synthetic additives (like
chlorhexidine), herbal sources for antimicrobial substances have also been
approached. One particularly popular extract in the Middle East is that of the
root of the Salvadora persica (S. persica) tree also called the "miswak" or
"siwak". In vitro, the S. persica root showed a strong growth inhibitory
effect on Aggregatibacter actinomicetemcomitans, Porphyromonas gingivalis and
Streptococcus mutans. In general it is suggested that gramnegative bacteria are
more susceptible for S. persica roots. However nothing is known about the
effect of S. persica roots on the viability of plaque bacteria.
Another very important characteristic of antimicrobials is that they can adhere
to soft and hard tissues and dental plaque in the oral cavity for some time.
Subsequently they start releasing to saliva and dental plaque and therewith
extend there action for a longer time, which is called substantivity. Regarding
S. persica and substantivity no data are available.
Study objective
To get insight in the effect of S. persica roots on the viability and bacterial
composition of dental plaque and saliva
Study design
Single armed comparative trial
Study burden and risks
The burden for the volunteers is that they cannot brush their teeth early in
the morning on the survey day, during the study period they need to chew S.
persica root three times a day for 1 min. There are no predictable risks in
this study.
A. Deusinglaan 1
Groningen 9713 AV
NL
A. Deusinglaan 1
Groningen 9713 AV
NL
Listed location countries
Age
Inclusion criteria
Volunteers are recruited at the Dentistry and Oral Hygiene academy, University Medical Center Groningen, University of Groningen.
- Minimal 5 natural permanent teeth per quadrant present.
- Good health of the subjects
Exclusion criteria
Recent use of antibiotics (3 months) prior to the start of the study
Recent use of mouth rinses and/or S. persica oral hygiene products (1 month) prior to the start of the study
Smokers
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL44287.042.13 |