To elucidate the role of cortical inhibition in PGES (pilot).
ID
Source
Brief title
Condition
- Seizures (incl subtypes)
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
TMS measures of cortical excitability (Motor threshold, Motor evoked potential
amplitude, cortical silent period, short and long recovery curves).
Secondary outcome
Serum levels of anti-epileptic medication
Background summary
People suffering from epilepsy are more likely to die suddenly without apparent
cause than people without the disease. This is termed SUDEP, sudden unexpected
death in epilepsy. In recent years, several features associated with epilepsy
and seizures have been linked to SUDEP. Post-ictal generalised EEG suppression
activity (PGES) is one of them. This phenomenon is often seen in people with
convulsive seizures. The mechanism underlying PGES is not well understood. It
has been proposed that it is due to excessive cortical inhibition in reaction
to the convulsive seizure. Transcranial magnetic stimulation (TMS) is a
promising technique to study inhibitory networks in the peri-ictal state.
Study objective
To elucidate the role of cortical inhibition in PGES (pilot).
Study design
observational pilot study
Study burden and risks
TMS is a safe technique that is usually well tolerated. TMS will be done every
morning during 5 days (baseline) and a maximum of 3 times in the post-ictal
phase. TMS can elicit seizure in people prone to seizures; the risk has been
estimated at 2.8% in people with epilepsy who are tapering anti-epileptic
medication (Schrader et al., 2004). While this could be seen as an adverse
effect, this is not unfavourable in this pre-surgical setting where patients
are admitted especially for seizure recordings.
Achterweg 5
Heemstede 2103SW
NL
Achterweg 5
Heemstede 2103SW
NL
Listed location countries
Age
Inclusion criteria
- Aged 18 years or over
- Frequent seizures (any type) >1 per week
- Frequent convulsive seizures (>1 per 2 months)
- Recurring nocturnal seizures
Exclusion criteria
- Pregnancy
- Use or medication other than anti-epileptic drugs that alter cortical excitability (b-blockers)
- performance IQ <80
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL45936.058.13 |