Non-invasive localization of the site of origin of idiopathic ventricular arrhythmias
ID
Source
Brief title
Condition
- Cardiac arrhythmias
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
1) Correct prediction of anatomical compartment and site of origin within that
compartment of ventricular ectopy by integrated electrocardiographic mapping
tool.
2) Correct depiction of endocardial (and epicardial) activation sequence
(*mapping*) of right ventricle and/or left ventricle
Secondary outcome
None
Background summary
Idiopathic ventricular arrhythmias usually originate in the outflow area of the
heart. This is a complex anatomic area comprising right ventricular outflow
tract, pulmonic artery, left ventricular outflow tract, aortic cusps, CS and
coronary veins, mitral annulus and epicardial anterior crux. Detailed data on
the site of origin obtained by a non-invasive mapping tool such as integrated
electrocardiographic mapping prior to the procedure may facilitate the mapping
procedure by narrowing down the number of potential anatomical structures from
which the ventricular ectopy may originate and thus shorten procedure time and
reduce the number of anatomical structures that will have to be mapped
invasively.
Study objective
Non-invasive localization of the site of origin of idiopathic ventricular
arrhythmias
Study design
Observational study utilizing additional non-invasive measurements
Study burden and risks
Patients will have to undergo one additional extended electrocardiographic
registration by means of a 64-electrode set. The cardiac MRI - that is
routinely obtained in the work-up for radiofrequency ablation of idiopathic
ventricular ectopy - will be utilized for reconstruction of the cardiac and
thoracic geometry. Since no additional invasive procedures are required, there
is no additional risk for the patient. Potential benefit of participating is
that beforehand more information is available on the endocardial activation and
epicardial activation within the heart and that the mapping for the site of
origin can be conducted more effectively.
Meibergdreef 9
Amsterdam 1105AZ
NL
Meibergdreef 9
Amsterdam 1105AZ
NL
Listed location countries
Age
Inclusion criteria
Patients scheduled for elective radiofrequency catheter ablation of idiopathic left or right ventricular tachycardia or idiopathic left or right ventricular extrasystoly.
Exclusion criteria
1) Unwillingness to participate
2) Not able to undergo MRI scanning (cardiac device, claustrophobia)
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL45872.018.13 |