Objective: Our general objective is to investigate the neurobiological substrates of a broader ADHD phenotype.
ID
Source
Brief title
Condition
- Developmental disorders NEC
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Main study parameter/endpoint
(1) Task related brain activity (BOLD-signal change) and connectivity measures
from fMRI
(2) Neuropsychological performance measures collected with computerized tasks
Secondary outcome
Secondary study parameters/endpoints
(1) Resting-state functional connectivity, assessed with resting-state fMRI
(2) Symptoms of ADHD from symptom rating scales (CBCL/TRF/SWAN)
(3) White matter integrity, assessed using tract-based FA (Fractional
Anisotropy) measures from DTI (Diffusion Tensor Imaging)
(4) Genotype on risk genes for ADHD
Background summary
Rationale: Recent studies point toward a more heterogeneous aetiology of
Attention Deficit Hyperactivity Disorder (ADHD), considering multiple pathways
that might separately lead to the disorder. In this protocol we propose to
investigate several cognitive domains that are implied in ADHD on both a
neuropsychological and a functional Magnetic Resonance Imaging (fMRI) level. An
important aspect of this project is the inclusions of a third group of children
(aside from children with ADHD and typically developing controls) with symptoms
of ADHD, but without a diagnosis of ADHD.
Study objective
Objective: Our general objective is to investigate the neurobiological
substrates of a broader ADHD phenotype.
Study design
Study design: We propose to conduct a cross-sectional combined
neuropsychological and MRI-study to investigate brain activity and connectivity
in ADHD.
Study burden and risks
Nature and extent of the burden and risks associated with participation,
benefit and group relatedness: Participants will be asked to perform
neuropsychological tasks and to undergo an MRI-scan lasting approximately 60
minutes. Subjects will be prepared for MR-scanning using an MR-simulation
procedure. Incidental findings of structural cerebral pathology requiring
medical treatment may occur. If this happens, the subject and his/her parents
will be notified. No immediate benefits for subjects are to be expected from
participation in this study. In the long run, increased understanding of the
aetiology and pathophysiology of ADHD may contribute to refined diagnosis and
an improved specificity of treatment options.
Heidelberglaan 100
Utrecht 3584 CX
NL
Heidelberglaan 100
Utrecht 3584 CX
NL
Listed location countries
Age
Inclusion criteria
Inclusion criteria for parents:
• No additional criteria if a child meets all of the inclusion criteria;General inclusion criteria for all subject groups (excluding parents):
• Aged 6 through 18 years at first scan
• Ability to speak and comprehend Dutch;Inclusion criteria for subjects with ADHD
• Clinical DSM-IV diagnosis of ADHD, supported by the Diagnostic Interview Schedule for Children (DISC) ;Inclusion criteria for control subjects
• No DSM-IV diagnosis, according to the DISC
• No scores in the clinical range on any scale of the Child Behavior Checklist (CBCL) as reported by one of the parents.;Inclusion criteria for subjects with a psychiatric diagnosis but no diagnosis of ADHD
• Any clinical DSM-IV diagnosis except ADHD, supported by the DISC interview
• A score in the subclinical or clinical range of the CBCL subscale of Attention Problems as reported by one of the parents.
Exclusion criteria
Mental retardation (IQ < 70)
Major illness of the cardiovascular, endocrine, pulmonal or the gastrointestinal system
Presence of interfering metal objects in or around the body (eg. pacemaker)
History of or present neurological disorder. A neurological disorder is defined as any disorder that requires care from a neurologist.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL40444.041.12 |