In this study, we want to investigate whether obese children perform differently than normal weight children (data already generated) on tasks of sensitivity to reward and executive functioning.
ID
Source
Brief title
Condition
- Glucose metabolism disorders (incl diabetes mellitus)
- Appetite and general nutritional disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
- scores of the excecutive function test and sensitvity to reward tests
- questionnaire scores of the BIS/BAS and CBSL filled in by the parents
- length and weigth of the child
- genetic testing (optional)
Secondary outcome
-
Background summary
Type 2 diabetes (T2D) is a multifactorial disorder. The leading risk factor for
T2D is obesity. T2D and obesity have a strong genetic component and their
susceptibility genes are partially the same. Studies of the genetics of obesity
and T2D are hampered by the heterogeneity of the phenotypes. In addition, this
heterogeneity complicates the prevention and treatment of the diseases. This
problem may be solved by creating subgroups of patients based on endophenotypes
which are more proximal to the biological aetiology of the disease. Based on
the overlap in the brain circuitry involved in food intake and addictive
behaviour, we propose to study the association of obesity and overweight with a
range of addiction-related candidate endophenotypes.
Study objective
In this study, we want to investigate whether obese children perform
differently than normal weight children (data already generated) on tasks of
sensitivity to reward and executive functioning.
Study design
We will test the performance of 45 obese children on an extensive and validated
battery of executive functioning and sensitivity to reward tasks. The children,
aged 6-12 years, will recruited from the obesity outpatient clinic of the
Slotervaart hospital. This study will enable us to examine the relationship of
both overweight and obesity with a broad range of candidate endophenotypes.
Study burden and risks
The main burden is time and the optional blood sample for genetic testing. This
blood sample will be combined with the oral glucose tolerance test (oGTT),
which is done as standard of care.
Van der Boechhorststraat 1
Amsterdam 1081 BT
NL
Van der Boechhorststraat 1
Amsterdam 1081 BT
NL
Listed location countries
Age
Inclusion criteria
- age 6-12 years old
- obesity, as defined by a Z-BMI >2.3
- Caucasian
Exclusion criteria
children with a physical illness
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL24617.029.08 |