To evaluate the validity of the SRT for assessing the exercise capacity of patients with cancer during chemotherapy.
ID
Source
Brief title
Condition
- Miscellaneous and site unspecified neoplasms malignant and unspecified
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The primary outcomes will be the level of agreement between peak VO2 (VO2peak)
and peak power (Wpeak) as assessed with a CPET and the peak power (Wpeak) as
assessed with the SRT.
Secondary outcome
Secondary study outcomes will include fatigue and health-related quality of
life (HRQOL).
Background summary
Physiotherapists use exercise diagnostics to determine patients* fitness level
prior to the start of an exercise regimen, to adjust an exercise program when
necessary, and to evaluate the effectiveness of such a program. Regular testing
during the course of an exercise program is necessary to adjust the intensity
of the exercise. A symptom limited incremental exercise test with
breath-by-breath gas analysis - also know as a cardiopulmonary exercise test
(CPET) - is considered to be the gold standard to assess cardiorespiratory
fitness. However, this test is not available in typical primary care
physiotherapy practices because of lack of expertise in this area, the
inability to meet safety guidelines, and the expense of the equipment needed.
The CPET can also be burdensome for the patient. In daily clinical practice,
submaximal exercise tests are often used as an alternative to the CPET. These
tests can be performed relatively easily by physiotherapists, are less
demanding of patients, and are less expensive to perform. The Steep Ramp Test
(SRT) is a submaximal test alternative to the CPET for tailoring aerobic
exercise during chemotherapy treatment. The SRT has been validated in other
populations, but not yet in adults with cancer undergoing chemotherapy.
Study objective
To evaluate the validity of the SRT for assessing the exercise capacity of
patients with cancer during chemotherapy.
Study design
Cohort study
Study burden and risks
In total, 50 consenting patients will undergo an extra CPET and will complete a
questionnaire at the start of chemotherapy (T0) and 9 weeks after the first
measurement (T1).
Plesmanlaan 121
Amsterdam 1066CX
NL
Plesmanlaan 121
Amsterdam 1066CX
NL
Listed location countries
Age
Inclusion criteria
Patients with cancer who will undergo chemotherapy and who have decided to participate in a physiotherapeutic intervention during their chemotherapy treatment.
Approval of treating physician to participate in this study.
Exclusion criteria
Patients with comorbid conditions which would contraindicate participation to a VO2max test.
1. Serious orthopedic conditions
2. Serious cardiovascular or cardiopulmonary conditions (or risks)
Patients with a high risk profile for cardiovascular events according to the ACSM guidelines
3. Patients suffering from malnutrition as evidenced by a BMI < 18 kg/m2, unintended weight loss of more than 5% per month, or more than 10% unintended weight loss during the previous 6 month
4. Serious psychiatric or cognitive problems
5. Lack of basic fluency in the Dutch language.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL44278.031.13 |